Factors That Influence Microdialysis Recovery. Comparison of Experimental and Theoretical Microdialysis Recoveries in Rat Liver

• Published in: Journal of pharmaceutical sciences Vol. 86; no. 8; pp. 958 - 966
• Main Authors: Stenken, Julie A., Lunte, Craig E., Southard, Marylee Z., Ståhle, Lars
• Format: Journal Article
• Language: English
• Published: New York Elsevier Inc 01.08.1997; John Wiley & Sons, Inc; Wiley; American Pharmaceutical Association
• Subjects: Analysis; Animals; Antipyrine - pharmacokinetics; Biological and medical sciences; Cytochrome P-450 CYP1A2 - metabolism; Cytochrome P-450 CYP1A2 Inhibitors; General pharmacology; Liver - enzymology; Liver - metabolism; Medical sciences; Medicin och hälsovetenskap; Microdialysis; Models, Biological; Pharmacology. Drug treatments; Phenacetin - pharmacokinetics; Rats; Rats, Sprague-Dawley; Biological fluid; Rat; Liver; Variations; Recovery; Separation method; Tissue; Enzymatic activity; Diffusion; Unspecific monooxygenase; Enzyme; Digestive system; Cytochrome P450; Sample; Interaction; Rodentia; Metabolism; Forecasting; Extracellular fluid; Vertebrata; Mammalia; Microdialysis; Animal; Limiting factor; Drug-metabolizing enzyme; Models; Oxidoreductases

Inhibition of metabolic processes was used to assess the possible change in the recovery of material from a microdialysis probe implanted in vivo in rat liver. Phenacetin and antipyrine were perfused through a microdialysis probe implanted in the liver. Inhibition of phenacetin and antipyrine metabo...