Comparison of two delayed strategies for renal replacement therapy initiation for severe acute kidney injury (AKIKI 2): a multicentre, open-label, randomised, controlled trial

• Published in: The Lancet (British edition) Vol. 397; no. 10281; pp. 1293 - 1300
• Main Authors: Gaudry, Stéphane, Hajage, David, Martin-Lefevre, Laurent, Lebbah, Saïd, Louis, Guillaume, Moschietto, Sébastien, Titeca-Beauport, Dimitri, Combe, Béatrice La, Pons, Bertrand, de Prost, Nicolas, Besset, Sébastien, Combes, Alain, Robine, Adrien, Beuzelin, Marion, Badie, Julio, Chevrel, Guillaume, Bohé, Julien, Coupez, Elisabeth, Chudeau, Nicolas, Barbar, Saber, Vinsonneau, Christophe, Forel, Jean-Marie, Thevenin, Didier, Boulet, Eric, Lakhal, Karim, Aissaoui, Nadia, Grange, Steven, Leone, Marc, Lacave, Guillaume, Nseir, Saad, Poirson, Florent, Mayaux, Julien, Asehnoune, Karim, Geri, Guillaume, Klouche, Kada, Thiery, Guillaume, Argaud, Laurent, Rozec, Bertrand, Cadoz, Cyril, Andreu, Pascal, Reignier, Jean, Ricard, Jean-Damien, Quenot, Jean-Pierre, Dreyfuss, Didier
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 03.04.2021; Elsevier B.V; Elsevier Limited; Elsevier
• Subjects: Acidosis; Acute Kidney Injury - mortality; Acute Kidney Injury - therapy; Aged; Aged, 80 and over; Anuria; Blood; Blood levels; Dialysate; Edema; Female; France; Hospitals; Humans; Injuries; Intensive care; Intensive care units; Intensive Care Units - organization & administration; Kidney diseases; Kidneys; Life Sciences; Male; Medical equipment; Metabolic acidosis; Metabolism; Middle Aged; Mortality; Nitrogen; Oliguria; Optimization; Patients; Population studies; Prospective Studies; Randomization; Renal replacement therapy; Renal Replacement Therapy - methods; Renal Replacement Therapy - statistics & numerical data; Severity of Illness Index; Strategy; Systematic review; Therapy; Time-to-Treatment; Urea; France

Delaying renal replacement therapy (RRT) for some time in critically ill patients with severe acute kidney injury and no severe complication is safe and allows optimisation of the use of medical devices. Major uncertainty remains concerning the duration for which RRT can be postponed without risk. O...