Monitoring bioactive and total antibody concentrations for continuous process control by surface plasmon resonance spectroscopy

• Published in: Engineering in life sciences Vol. 19; no. 10; pp. 681 - 690
• Main Authors: Zschätzsch, Marlen, Ritter, Paul, Henseleit, Anja, Wiehler, Klaus, Malik, Sven, Bley, Thomas, Walther, Thomas, Boschke, Elke
• Format: Journal Article
• Language: English
• Published: Germany John Wiley and Sons Inc 01.10.2019
• Subjects: antibody; bioactive and total antibody concentration; monitoring; surface plasmon resonance; bioactive and total antibody concentration; antibody; monitoring; surface plasmon resonance

Monoclonal antibodies have become an increasingly important part of fundamental research and medical applications. To meet the high market demand for monoclonal antibodies in the biopharmaceutical sector, industrial manufacturing needs to be achieved by large scale, highly productive and consistent...