Testin is a tumor suppressor and prognostic marker in breast cancer

• Published in: Cancer science Vol. 103; no. 12; pp. 2092 - 2101
• Main Authors: Zhu, Jiang, Li, Xiaoyan, Kong, Xiangnan, Moran, Meena S., Su, Peng, Haffty, Bruce G., Yang, Qifeng
• Format: Journal Article
• Language: English
• Published: England John Wiley and Sons Inc 01.12.2012
• Subjects: Angiogenesis; Animal models; Animals; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Breast - metabolism; Breast - pathology; Breast cancer; Breast Neoplasms - genetics; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Carcinoma; Carcinoma, Ductal, Breast - genetics; Carcinoma, Ductal, Breast - metabolism; Carcinoma, Ductal, Breast - pathology; Carcinoma, Intraductal, Noninfiltrating - genetics; Carcinoma, Intraductal, Noninfiltrating - metabolism; Carcinoma, Intraductal, Noninfiltrating - pathology; Cell Proliferation; Cytoskeletal Proteins - genetics; Cytoskeletal Proteins - metabolism; Data processing; Disease-Free Survival; Female; Gelatinase A; Humans; Hyperplasia; Invasiveness; LIM Domain Proteins - genetics; LIM Domain Proteins - metabolism; Metastases; Mice; Mice, Nude; Multivariate analysis; NIH 3T3 Cells; Original; Prognosis; RNA-mediated interference; Tumor suppressor genes; Tumors; Xenograft Model Antitumor Assays; Xenografts

The testin (TES) gene was previously identified in the fragile chromosomal region FRA7G at 7q31.2. In the present study, we aimed to investigate the candidate tumor suppressor function of TES and explore its correlations to clinicopathologic features and prognosis in breast cancer. In clinical sampl...