Quercetin alleviates microglial-induced inflammation after traumatic brain injury via the PGC-1α/Nrf2 pathway dependent on HDAC3 inhibition

• Published in: Brain research bulletin Vol. 217; p. 111080
• Main Authors: Zhai, Xiaofu, Wang, Ziyu, Gao, Juemin
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.10.2024; Elsevier
• Subjects: Animals; Apoptosis - drug effects; Brain Injuries, Traumatic - drug therapy; Brain Injuries, Traumatic - metabolism; Brain Injuries, Traumatic - pathology; Disease Models, Animal; HDAC3; Histone Deacetylases - metabolism; Inflammation; Inflammation - drug therapy; Inflammation - metabolism; Male; Mice; Mice, Inbred C57BL; Microglia - drug effects; Microglia - metabolism; Neuroinflammatory Diseases - drug therapy; Neuroinflammatory Diseases - metabolism; Neurons - drug effects; Neurons - metabolism; Neurons - pathology; Neuroprotective Agents - pharmacology; NF-E2-Related Factor 2 - metabolism; Nrf2; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism; PGC-1α; Quercetin; Quercetin - pharmacology; Signal Transduction - drug effects; Traumatic brain injury; Inflammation; PGC-1α; Traumatic brain injury; HDAC3; Nrf2; Quercetin

Inflammation and neuronal apoptosis play a key role in traumatic brain injury (TBI). Quercetin (Que) has been shown to exhibit a neuroprotective effect after TBI, but the underlying molecular mechanism remains unclear. In this study, We established a weight-drop mouse model to illustrate the effects...