Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody

• Published in: Nature (London) Vol. 583; no. 7815; pp. 290 - 295
• Main Authors: Pinto, Dora, Park, Young-Jun, Beltramello, Martina, Walls, Alexandra C., Tortorici, M. Alejandra, Bianchi, Siro, Jaconi, Stefano, Culap, Katja, Zatta, Fabrizia, De Marco, Anna, Peter, Alessia, Guarino, Barbara, Spreafico, Roberto, Cameroni, Elisabetta, Case, James Brett, Chen, Rita E., Havenar-Daughton, Colin, Snell, Gyorgy, Telenti, Amalio, Virgin, Herbert W., Lanzavecchia, Antonio, Diamond, Michael S., Fink, Katja, Veesler, David, Corti, Davide
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 09.07.2020; Nature Publishing Group
• Subjects: 101/28; 13/1; 13/31; 631/250/255/2514; 631/326/596/4130; 631/61/51/1568; Angiotensin-Converting Enzyme 2; Animals; Antibodies; Antibodies, Monoclonal - chemistry; Antibodies, Monoclonal - immunology; Antibodies, Monoclonal - pharmacology; Antibodies, Neutralizing - chemistry; Antibodies, Neutralizing - immunology; Antibodies, Neutralizing - pharmacology; Antibodies, Viral - chemistry; Antibodies, Viral - immunology; Antibodies, Viral - pharmacology; Antibody-Dependent Cell Cytotoxicity - drug effects; Antibody-Dependent Cell Cytotoxicity - immunology; B-Lymphocytes - immunology; Betacoronavirus - chemistry; Betacoronavirus - drug effects; Betacoronavirus - immunology; Binding; Chlorocebus aethiops; Coronaviridae; Coronavirus Infections - immunology; Coronavirus Infections - prevention & control; Coronavirus Infections - therapy; Coronavirus Infections - virology; Coronaviruses; COVID-19; Cross Reactions - drug effects; Cross Reactions - immunology; Cryoelectron Microscopy; Disease transmission; Electron microscopy; Enzymes; Epidemics; Epitopes; Epitopes, B-Lymphocyte - chemistry; Epitopes, B-Lymphocyte - immunology; Glycan; Glycoproteins; HEK293 Cells; Humanities and Social Sciences; Humans; Immune Evasion - immunology; Immunoglobulin Fab Fragments - chemistry; Immunoglobulin Fab Fragments - immunology; Immunoglobulin Fab Fragments - pharmacology; Immunologic Memory - immunology; Immunological memory; Killer Cells, Natural - drug effects; Killer Cells, Natural - immunology; Life Sciences; Lymphocytes B; Memory cells; Microscopy; Middle East respiratory syndrome; Models, Molecular; Monoclonal antibodies; multidisciplinary; Neutralization; Neutralization Tests; Pandemics; Pandemics - prevention & control; Peptidyl-Dipeptidase A - chemistry; Peptidyl-Dipeptidase A - metabolism; Pneumonia, Viral - immunology; Pneumonia, Viral - prevention & control; Pneumonia, Viral - therapy; Pneumonia, Viral - virology; Prophylaxis; Receptors; Respiratory diseases; Sarbecovirus; SARS Virus - chemistry; SARS Virus - drug effects; SARS Virus - immunology; SARS-CoV-2; Science; Science (multidisciplinary); Severe Acute Respiratory Syndrome - immunology; Severe Acute Respiratory Syndrome - virology; Severe acute respiratory syndrome coronavirus 2; Spike Glycoprotein, Coronavirus - chemistry; Spike Glycoprotein, Coronavirus - immunology; Vaccines; Vero Cells; Viral diseases; Viruses; Zoonoses

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly emerged coronavirus that is responsible for the current pandemic of coronavirus disease 2019 (COVID-19), which has resulted in more than 3.7 million infections and 260,000 deaths as of 6 May 2020 1 , 2 . Vaccine and therapeutic...