Cancer-associated fibroblast regulation by microRNAs promotes invasion of oral squamous cell carcinoma

• Published in: Oral oncology Vol. 110; p. 104909
• Main Authors: Matos, Leandro Luongo, Menderico Junior, Gilberto Mendes, Theodoro, Thérèse Rachell, Pasini, Fatima Solange, Ishikawa, Marina de Menezes, Ribeiro, Andrômeda Aryane Bomtempo, de Mello, Evandro Sobroza, Pinhal, Maria Aparecida da Silva, Moyses, Raquel Ajub, Kulcsar, Marco Aurelio Vamondes, Dedivitis, Rogério Aparecido, Cernea, Claudio Roberto, Kowalski, Luiz Paulo
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.11.2020
• Subjects: Carcinogenesis; Carcinoma, squamous cell; Hematology, Oncology, and Palliative Medicine; microRNAs; Mouth; Neoplasm invasiveness; Otolaryngology; microRNAs; Carcinoma, squamous cell; Neoplasm invasiveness; Carcinogenesis; Mouth

•There is interaction between miRNAs and the extracellular matrix in OSCC.•miR-1-3p, miR-133a-3 and miR-21-5p are involved in the process of OSCC invasion.•MMP-2 and MMP-9 in CAFs are related to ECM degradation in deep tumors.•miR-133a-3p expression could be related to OS and DFS in OSCC. The object...