Cancer-associated fibroblast regulation by microRNAs promotes invasion of oral squamous cell carcinoma
•There is interaction between miRNAs and the extracellular matrix in OSCC.•miR-1-3p, miR-133a-3 and miR-21-5p are involved in the process of OSCC invasion.•MMP-2 and MMP-9 in CAFs are related to ECM degradation in deep tumors.•miR-133a-3p expression could be related to OS and DFS in OSCC. The object...
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| Published in | Oral oncology Vol. 110; p. 104909 |
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| Main Authors | , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Elsevier Ltd
01.11.2020
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| Subjects | |
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| Abstract | •There is interaction between miRNAs and the extracellular matrix in OSCC.•miR-1-3p, miR-133a-3 and miR-21-5p are involved in the process of OSCC invasion.•MMP-2 and MMP-9 in CAFs are related to ECM degradation in deep tumors.•miR-133a-3p expression could be related to OS and DFS in OSCC.
The objective of the present study was to evaluate the role of microRNA-mediated remodeling of the extracellular matrix in the process of tumor invasion of oral squamous cell carcinoma and to evaluate its relationship with the prognosis of these patients. This was a retrospective study on material from the paraffin blocks of patients operated on for oral squamous cell carcinoma, in addition to a group of healthy oral mucosa samples of paired patients. miR-1-3p, miR-133-3p, and miR-21-5p were differentially expressed between the superficial and deep tumor groups. miR-21-5p was the one with the greatest accuracy in the differentiation between superficial and deep tumors. By immunohistochemistry, the group of deep tumors showed greater immunoreactivity to matrix metalloproteinases 2 and 9 and laminin α in tumor-associated fibroblasts, with consequent degradation of the basal membrane, measured by greater loss of continuity of type IV collagen. This process was also associated with lower and higher expression of miR-1-3p and miR-21-5p, respectively. There was also a trend toward better overall and disease-free survival rates in patients with higher miR-133a-3p. The present study showed the interaction between microRNAs and extracellular matrix remodeling in oral squamous cell carcinoma. |
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| AbstractList | The objective of the present study was to evaluate the role of microRNA-mediated remodeling of the extracellular matrix in the process of tumor invasion of oral squamous cell carcinoma and to evaluate its relationship with the prognosis of these patients. This was a retrospective study on material from the paraffin blocks of patients operated on for oral squamous cell carcinoma, in addition to a group of healthy oral mucosa samples of paired patients. miR-1-3p, miR-133-3p, and miR-21-5p were differentially expressed between the superficial and deep tumor groups. miR-21-5p was the one with the greatest accuracy in the differentiation between superficial and deep tumors. By immunohistochemistry, the group of deep tumors showed greater immunoreactivity to matrix metalloproteinases 2 and 9 and laminin α in tumor-associated fibroblasts, with consequent degradation of the basal membrane, measured by greater loss of continuity of type IV collagen. This process was also associated with lower and higher expression of miR-1-3p and miR-21-5p, respectively. There was also a trend toward better overall and disease-free survival rates in patients with higher miR-133a-3p. The present study showed the interaction between microRNAs and extracellular matrix remodeling in oral squamous cell carcinoma.The objective of the present study was to evaluate the role of microRNA-mediated remodeling of the extracellular matrix in the process of tumor invasion of oral squamous cell carcinoma and to evaluate its relationship with the prognosis of these patients. This was a retrospective study on material from the paraffin blocks of patients operated on for oral squamous cell carcinoma, in addition to a group of healthy oral mucosa samples of paired patients. miR-1-3p, miR-133-3p, and miR-21-5p were differentially expressed between the superficial and deep tumor groups. miR-21-5p was the one with the greatest accuracy in the differentiation between superficial and deep tumors. By immunohistochemistry, the group of deep tumors showed greater immunoreactivity to matrix metalloproteinases 2 and 9 and laminin α in tumor-associated fibroblasts, with consequent degradation of the basal membrane, measured by greater loss of continuity of type IV collagen. This process was also associated with lower and higher expression of miR-1-3p and miR-21-5p, respectively. There was also a trend toward better overall and disease-free survival rates in patients with higher miR-133a-3p. The present study showed the interaction between microRNAs and extracellular matrix remodeling in oral squamous cell carcinoma. •There is interaction between miRNAs and the extracellular matrix in OSCC.•miR-1-3p, miR-133a-3 and miR-21-5p are involved in the process of OSCC invasion.•MMP-2 and MMP-9 in CAFs are related to ECM degradation in deep tumors.•miR-133a-3p expression could be related to OS and DFS in OSCC. The objective of the present study was to evaluate the role of microRNA-mediated remodeling of the extracellular matrix in the process of tumor invasion of oral squamous cell carcinoma and to evaluate its relationship with the prognosis of these patients. This was a retrospective study on material from the paraffin blocks of patients operated on for oral squamous cell carcinoma, in addition to a group of healthy oral mucosa samples of paired patients. miR-1-3p, miR-133-3p, and miR-21-5p were differentially expressed between the superficial and deep tumor groups. miR-21-5p was the one with the greatest accuracy in the differentiation between superficial and deep tumors. By immunohistochemistry, the group of deep tumors showed greater immunoreactivity to matrix metalloproteinases 2 and 9 and laminin α in tumor-associated fibroblasts, with consequent degradation of the basal membrane, measured by greater loss of continuity of type IV collagen. This process was also associated with lower and higher expression of miR-1-3p and miR-21-5p, respectively. There was also a trend toward better overall and disease-free survival rates in patients with higher miR-133a-3p. The present study showed the interaction between microRNAs and extracellular matrix remodeling in oral squamous cell carcinoma. Highlights•There is interaction between miRNAs and the extracellular matrix in OSCC. •miR-1-3p, miR-133a-3 and miR-21-5p are involved in the process of OSCC invasion. •MMP-2 and MMP-9 in CAFs are related to ECM degradation in deep tumors. •miR-133a-3p expression could be related to OS and DFS in OSCC. |
| ArticleNumber | 104909 |
| Author | Pinhal, Maria Aparecida da Silva Dedivitis, Rogério Aparecido Menderico Junior, Gilberto Mendes Cernea, Claudio Roberto Moyses, Raquel Ajub Kowalski, Luiz Paulo Theodoro, Thérèse Rachell Kulcsar, Marco Aurelio Vamondes Matos, Leandro Luongo Ribeiro, Andrômeda Aryane Bomtempo de Mello, Evandro Sobroza Pasini, Fatima Solange Ishikawa, Marina de Menezes |
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| Cites_doi | 10.1002/hed.10221 10.1016/j.oraloncology.2017.05.020 10.1007/BF00690293 10.1111/jop.12172 10.1186/s12885-015-1272-3 10.1007/s00262-011-1139-7 10.1002/hed.20275 10.1186/1476-4598-8-50 10.1016/j.amsu.2016.01.091 10.1016/j.mce.2011.09.022 10.1016/j.fertnstert.2013.10.042 10.3322/caac.21389 10.1016/j.bbadis.2012.10.013 10.1111/jop.12112 10.1371/journal.pone.0073009 10.1186/s12967-019-1853-z 10.1016/j.arbres.2015.10.016 10.1186/s12943-016-0512-8 10.1002/hed.25866 10.1007/s41548-019-00017-7 10.1186/s12943-017-0718-4 10.1016/j.pharmthera.2012.10.003 10.1038/jhg.2016.47 10.1371/journal.pone.0095193 10.1128/MCB.00479-08 10.1038/cddis.2016.224 10.1016/j.oooo.2014.03.023 10.1002/jcb.26182 10.1038/s41467-017-00985-8 10.1097/MEG.0b013e3283484795 10.1111/iep.12162 |
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| References | Liu, Chen, Zhang, Chen (b0130) 2019; 24 Lambert, Sauvaget, de Camargo, Sankaranarayanan (b0005) 2011; 23 Gabriely, Wurdinger, Kesari, Esau, Burchard, Linsley (b0160) 2008; 28 Jakob, Mattes, Kuffer, Unger, Hess, Bertlich (b0175) 2019; 41 Manikandan, Deva Magendhra Rao, Arunkumar, Manickavasagam, Rajkumar, Rajaraman (b0180) 2016; 15 Matias, Bordieri, Roberts, Cheever, Munk, Lipsky (b0065) 2019; 3 Zhang, Liu (b0075) 2013; 137 Pentenero, Gandolfo, Carrozzo (b0020) 2005; 27 Matos, Dedivitis, Kulcsar, de Mello, Alves, Cernea (b0015) 2017; 71 Aprelikova, Green (b0060) 2012; 61 Chen, Song, Yu, Cheng, Tong (b0170) 2019; 17 Theodoro, Matos, Cavalheiro, Justo, Nader, Pinhal (b0110) 2019; 17 He, Lin, Tian, Yu, Qiao (b0125) 2018; 119 Moreno-Moya, Vilella, Simon (b0050) 2014; 101 Diaz, Holsinger, Zuniga, Roberts, Sorensen (b0010) 2003; 25 Ba, Zhang, Yu, Li, Duan, Wang (b0095) 2019; 18 Baroni, Romero-Cordoba, Plantamura, Dugo, D'Ippolito, Cataldo (b0120) 2016; 7 Ribeiro, Borges, Cardoso, Candelori, Espíndola, Cassali (b0090) 2008; 44 Cress, Rabinovitz, Zhu, Nagle (b0100) 1995; 14 Widodo, Djati, Rifa'i (b0040) 2016; 7 Garnis, Chari, Buys, Zhang, Ng, Rosin (b0035) 2009; 8 Zhou, Chen, Wang, Lin, Zhang, Fan (b0080) 2014; 43 Hedback, Jensen, Specht, Fiehn, Therkildsen, Friis-Hansen (b0155) 2014; 9 Fullar, Dudas, Olah, Hollosi, Papp, Sobel (b0105) 2015; 15 Xiao, Liu, Gu, Ji (b0135) 2016; 52 Lydiatt, Patel, O'Sullivan, Brandwein, Ridge, Migliacci, Loomis, Shah (b0055) 2017; 67 Matos, Manfro, Santos, Stabenow, Mello, Alves (b0025) 2014; 118 Cochrane, Spoelstra, Richer (b0045) 2012; 357 Marsh, Pietras, McAllister (b0070) 2013; 1832 Brito, Gomes, Guimaraes, Campos, Gomez (b0150) 2014; 43 Yang, Ning, Ma, Liu, Shao, Shu (b0115) 2017; 16 Koshizuka, Hanazawa, Fukumoto, Kikkawa, Matsushita, Mataki (b0140) 2017; 62 Chen, Shi, Zhong, Huang, Luo, Huang (b0145) 2015; 96 Glentis, Oertle, Mariani, Chikina, El Marjou, Attieh (b0085) 2017; 8 Nouraee, Van Roosbroeck, Vasei, Semnani, Samaei, Naghshvar (b0165) 2013; 8 Pinto, de Matos, Palermo, Kulcsar, Cavalheiro, de Mello (b0030) 2014; 271 Matos (10.1016/j.oraloncology.2020.104909_b0025) 2014; 118 Yang (10.1016/j.oraloncology.2020.104909_b0115) 2017; 16 Koshizuka (10.1016/j.oraloncology.2020.104909_b0140) 2017; 62 Lydiatt (10.1016/j.oraloncology.2020.104909_b0055) 2017; 67 Aprelikova (10.1016/j.oraloncology.2020.104909_b0060) 2012; 61 Ba (10.1016/j.oraloncology.2020.104909_b0095) 2019; 18 Diaz (10.1016/j.oraloncology.2020.104909_b0010) 2003; 25 Moreno-Moya (10.1016/j.oraloncology.2020.104909_b0050) 2014; 101 Glentis (10.1016/j.oraloncology.2020.104909_b0085) 2017; 8 Zhang (10.1016/j.oraloncology.2020.104909_b0075) 2013; 137 He (10.1016/j.oraloncology.2020.104909_b0125) 2018; 119 Pentenero (10.1016/j.oraloncology.2020.104909_b0020) 2005; 27 Cress (10.1016/j.oraloncology.2020.104909_b0100) 1995; 14 Jakob (10.1016/j.oraloncology.2020.104909_b0175) 2019; 41 Matias (10.1016/j.oraloncology.2020.104909_b0065) 2019; 3 Baroni (10.1016/j.oraloncology.2020.104909_b0120) 2016; 7 Lambert (10.1016/j.oraloncology.2020.104909_b0005) 2011; 23 Cochrane (10.1016/j.oraloncology.2020.104909_b0045) 2012; 357 Manikandan (10.1016/j.oraloncology.2020.104909_b0180) 2016; 15 Matos (10.1016/j.oraloncology.2020.104909_b0015) 2017; 71 Chen (10.1016/j.oraloncology.2020.104909_b0145) 2015; 96 Gabriely (10.1016/j.oraloncology.2020.104909_b0160) 2008; 28 Xiao (10.1016/j.oraloncology.2020.104909_b0135) 2016; 52 Zhou (10.1016/j.oraloncology.2020.104909_b0080) 2014; 43 Chen (10.1016/j.oraloncology.2020.104909_b0170) 2019; 17 Marsh (10.1016/j.oraloncology.2020.104909_b0070) 2013; 1832 Widodo (10.1016/j.oraloncology.2020.104909_b0040) 2016; 7 Pinto (10.1016/j.oraloncology.2020.104909_b0030) 2014; 271 Hedback (10.1016/j.oraloncology.2020.104909_b0155) 2014; 9 Ribeiro (10.1016/j.oraloncology.2020.104909_b0090) 2008; 44 Fullar (10.1016/j.oraloncology.2020.104909_b0105) 2015; 15 Brito (10.1016/j.oraloncology.2020.104909_b0150) 2014; 43 Garnis (10.1016/j.oraloncology.2020.104909_b0035) 2009; 8 Theodoro (10.1016/j.oraloncology.2020.104909_b0110) 2019; 17 Nouraee (10.1016/j.oraloncology.2020.104909_b0165) 2013; 8 Liu (10.1016/j.oraloncology.2020.104909_b0130) 2019; 24 |
| References_xml | – volume: 8 start-page: 50 year: 2009 ident: b0035 article-title: Genomic imbalances in precancerous tissues signal oral cancer risk publication-title: Mol Cancer – volume: 43 start-page: 211 year: 2014 end-page: 216 ident: b0150 article-title: Relationship between microRNA expression levels and histopathological features of dysplasia in oral leukoplakia publication-title: J Oral Pathol Med – volume: 118 start-page: 209 year: 2014 end-page: 217 ident: b0025 article-title: Tumor thickness as a predictive factor of lymph node metastasis and disease recurrence in T1N0 and T2N0 squamous cell carcinoma of the oral tongue publication-title: Oral Surg Oral Med Oral Pathol Oral Radiol – volume: 9 year: 2014 ident: b0155 article-title: MiR-21 expression in the tumor stroma of oral squamous cell carcinoma: an independent biomarker of disease free survival publication-title: PLoS ONE – volume: 44 start-page: 115 year: 2008 end-page: 121 ident: b0090 article-title: Expression of matrix metalloproteinasis and their tissue inhibitors in basal cell carcinoma publication-title: J Bras Patol Med Lab – volume: 96 start-page: 427 year: 2015 end-page: 432 ident: b0145 article-title: miR-1, regulated by LMP1, suppresses tumour growth and metastasis by targeting K-ras in nasopharyngeal carcinoma publication-title: Int J Exp Pathol – volume: 27 start-page: 1080 year: 2005 end-page: 1091 ident: b0020 article-title: Importance of tumor thickness and depth of invasion in nodal involvement and prognosis of oral squamous cell carcinoma: a review of the literature publication-title: Head Neck – volume: 62 start-page: 113 year: 2017 end-page: 121 ident: b0140 article-title: Dual-receptor (EGFR and c-MET) inhibition by tumor-suppressive miR-1 and miR-206 in head and neck squamous cell carcinoma publication-title: J Hum Genet – volume: 7 year: 2016 ident: b0120 article-title: Exosome-mediated delivery of miR-9 induces cancer-associated fibroblast-like properties in human breast fibroblasts publication-title: Cell Death Dis – volume: 14 start-page: 219 year: 1995 end-page: 228 ident: b0100 article-title: The alpha 6 beta 1 and alpha 6 beta 4 integrins in human prostate cancer progression publication-title: Cancer Metastasis Rev – volume: 16 start-page: 148 year: 2017 ident: b0115 article-title: Exosomal miRNAs and miRNA dysregulation in cancer-associated fibroblasts publication-title: Mol Cancer – volume: 17 start-page: 5441 year: 2019 end-page: 5446 ident: b0170 article-title: miRNA-10a promotes cancer cell proliferation in oral squamous cell carcinoma by upregulating GLUT1 and promoting glucose metabolism publication-title: Oncol Lett – volume: 3 start-page: 1 year: 2019 end-page: 8 ident: b0065 article-title: Small molecule inhibition of matrix metalloproteinases as a potential therapeutic for metastatic activity in squamous cell carcinoma publication-title: Oral Cancer – volume: 71 start-page: 47 year: 2017 end-page: 53 ident: b0015 article-title: External validation of the AJCC Cancer Staging Manual, 8th edition, in an independent cohort of oral cancer patients publication-title: Oral Oncol – volume: 8 start-page: 924 year: 2017 ident: b0085 article-title: Cancer-associated fibroblasts induce metalloprotease-independent cancer cell invasion of the basement membrane publication-title: Nat Commun – volume: 28 start-page: 5369 year: 2008 end-page: 5380 ident: b0160 article-title: MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators publication-title: Mol Cell Biol – volume: 8 year: 2013 ident: b0165 article-title: Expression, tissue distribution and function of miR-21 in esophageal squamous cell carcinoma publication-title: PLoS ONE – volume: 1832 start-page: 1070 year: 2013 end-page: 1078 ident: b0070 article-title: Fibroblasts as architects of cancer pathogenesis publication-title: Biochim Biophys Acta – volume: 67 start-page: 122 year: 2017 end-page: 137 ident: b0055 article-title: Head and neck cancers-major changes in the American Joint Committee on cancer eighth edition cancer staging manual: Head and Neck Cancers-Major 8th Edition Changes publication-title: CA Cancer J Clin – volume: 18 start-page: 2484 year: 2019 end-page: 2490 ident: b0095 article-title: Cancer associated fibroblasts are distinguishable from peri-tumor fibroblasts by biological characteristics in TSCC publication-title: Oncol Lett – volume: 23 start-page: 633 year: 2011 end-page: 641 ident: b0005 article-title: Epidemiology of cancer from the oral cavity and oropharynx publication-title: Eur J Gastroenterol Hepatol – volume: 357 start-page: 50 year: 2012 end-page: 59 ident: b0045 article-title: The role of miRNAs in progesterone action publication-title: Mol Cell Endocrinol – volume: 43 start-page: 585 year: 2014 end-page: 592 ident: b0080 article-title: A role for cancer-associated fibroblasts in inducing the epithelial-to-mesenchymal transition in human tongue squamous cell carcinoma publication-title: J Oral Pathol Med – volume: 15 start-page: 256 year: 2015 ident: b0105 article-title: Remodeling of extracellular matrix by normal and tumor-associated fibroblasts promotes cervical cancer progression publication-title: BMC Cancer – volume: 17 start-page: 103 year: 2019 ident: b0110 article-title: Crosstalk between tumor cells and lymphocytes modulates heparanase expression publication-title: J Transl Med – volume: 25 start-page: 267 year: 2003 end-page: 273 ident: b0010 article-title: Squamous cell carcinoma of the buccal mucosa: one institution's experience with 119 previously untreated patients publication-title: Head Neck – volume: 7 start-page: 9 year: 2016 end-page: 13 ident: b0040 article-title: Role of MicroRNAs in carcinogenesis that potential for biomarker of endometrial cancer publication-title: Ann Med Surg (Lond) – volume: 24 start-page: 929 year: 2019 end-page: 935 ident: b0130 article-title: MicroRNA-133 inhibits the growth and metastasis of the human lung cancer cells by targeting epidermal growth factor receptor publication-title: J BUON – volume: 61 start-page: 231 year: 2012 end-page: 237 ident: b0060 article-title: MicroRNA regulation in cancer-associated fibroblasts publication-title: Cancer Immunol Immunother – volume: 137 start-page: 200 year: 2013 end-page: 215 ident: b0075 article-title: Tumor stroma as targets for cancer therapy publication-title: Pharmacol Ther – volume: 52 start-page: 505 year: 2016 end-page: 511 ident: b0135 article-title: Expression of microRNA-133 inhibits epithelial-mesenchymal transition in lung cancer cells by directly targeting FOXQ1 publication-title: Arch Bronconeumol – volume: 41 start-page: 3499 year: 2019 end-page: 3515 ident: b0175 article-title: MicroRNA expression patterns in oral squamous cell carcinoma: hsa-mir-99b-3p and hsa-mir-100-5p as novel prognostic markers for oral cancer publication-title: Head Neck – volume: 271 start-page: 1747 year: 2014 end-page: 1754 ident: b0030 article-title: Tumor thickness as an independent risk factor of early recurrence in oral cavity squamous cell carcinoma publication-title: Eur Arch Otorhinolaryngol – volume: 101 start-page: 1516 year: 2014 end-page: 1523 ident: b0050 article-title: MicroRNA: key gene expression regulators publication-title: Fertil Steril – volume: 119 start-page: 338 year: 2018 end-page: 346 ident: b0125 article-title: MiR-133a-3p inhibits oral squamous cell carcinoma (OSCC) proliferation and invasion by suppressing COL1A1 publication-title: J Cell Biochem – volume: 15 start-page: 28 year: 2016 ident: b0180 article-title: Oral squamous cell carcinoma: microRNA expression profiling and integrative analyses for elucidation of tumourigenesis mechanism publication-title: Mol Cancer – volume: 25 start-page: 267 year: 2003 ident: 10.1016/j.oraloncology.2020.104909_b0010 article-title: Squamous cell carcinoma of the buccal mucosa: one institution's experience with 119 previously untreated patients publication-title: Head Neck doi: 10.1002/hed.10221 – volume: 71 start-page: 47 year: 2017 ident: 10.1016/j.oraloncology.2020.104909_b0015 article-title: External validation of the AJCC Cancer Staging Manual, 8th edition, in an independent cohort of oral cancer patients publication-title: Oral Oncol doi: 10.1016/j.oraloncology.2017.05.020 – volume: 14 start-page: 219 year: 1995 ident: 10.1016/j.oraloncology.2020.104909_b0100 article-title: The alpha 6 beta 1 and alpha 6 beta 4 integrins in human prostate cancer progression publication-title: Cancer Metastasis Rev doi: 10.1007/BF00690293 – volume: 43 start-page: 585 year: 2014 ident: 10.1016/j.oraloncology.2020.104909_b0080 article-title: A role for cancer-associated fibroblasts in inducing the epithelial-to-mesenchymal transition in human tongue squamous cell carcinoma publication-title: J Oral Pathol Med doi: 10.1111/jop.12172 – volume: 15 start-page: 256 year: 2015 ident: 10.1016/j.oraloncology.2020.104909_b0105 article-title: Remodeling of extracellular matrix by normal and tumor-associated fibroblasts promotes cervical cancer progression publication-title: BMC Cancer doi: 10.1186/s12885-015-1272-3 – volume: 61 start-page: 231 year: 2012 ident: 10.1016/j.oraloncology.2020.104909_b0060 article-title: MicroRNA regulation in cancer-associated fibroblasts publication-title: Cancer Immunol Immunother doi: 10.1007/s00262-011-1139-7 – volume: 27 start-page: 1080 year: 2005 ident: 10.1016/j.oraloncology.2020.104909_b0020 article-title: Importance of tumor thickness and depth of invasion in nodal involvement and prognosis of oral squamous cell carcinoma: a review of the literature publication-title: Head Neck doi: 10.1002/hed.20275 – volume: 8 start-page: 50 year: 2009 ident: 10.1016/j.oraloncology.2020.104909_b0035 article-title: Genomic imbalances in precancerous tissues signal oral cancer risk publication-title: Mol Cancer doi: 10.1186/1476-4598-8-50 – volume: 7 start-page: 9 year: 2016 ident: 10.1016/j.oraloncology.2020.104909_b0040 article-title: Role of MicroRNAs in carcinogenesis that potential for biomarker of endometrial cancer publication-title: Ann Med Surg (Lond) doi: 10.1016/j.amsu.2016.01.091 – volume: 44 start-page: 115 year: 2008 ident: 10.1016/j.oraloncology.2020.104909_b0090 article-title: Expression of matrix metalloproteinasis and their tissue inhibitors in basal cell carcinoma publication-title: J Bras Patol Med Lab – volume: 357 start-page: 50 year: 2012 ident: 10.1016/j.oraloncology.2020.104909_b0045 article-title: The role of miRNAs in progesterone action publication-title: Mol Cell Endocrinol doi: 10.1016/j.mce.2011.09.022 – volume: 101 start-page: 1516 year: 2014 ident: 10.1016/j.oraloncology.2020.104909_b0050 article-title: MicroRNA: key gene expression regulators publication-title: Fertil Steril doi: 10.1016/j.fertnstert.2013.10.042 – volume: 67 start-page: 122 issue: 2 year: 2017 ident: 10.1016/j.oraloncology.2020.104909_b0055 article-title: Head and neck cancers-major changes in the American Joint Committee on cancer eighth edition cancer staging manual: Head and Neck Cancers-Major 8th Edition Changes publication-title: CA Cancer J Clin doi: 10.3322/caac.21389 – volume: 1832 start-page: 1070 year: 2013 ident: 10.1016/j.oraloncology.2020.104909_b0070 article-title: Fibroblasts as architects of cancer pathogenesis publication-title: Biochim Biophys Acta doi: 10.1016/j.bbadis.2012.10.013 – volume: 271 start-page: 1747 year: 2014 ident: 10.1016/j.oraloncology.2020.104909_b0030 article-title: Tumor thickness as an independent risk factor of early recurrence in oral cavity squamous cell carcinoma publication-title: Eur Arch Otorhinolaryngol – volume: 43 start-page: 211 year: 2014 ident: 10.1016/j.oraloncology.2020.104909_b0150 article-title: Relationship between microRNA expression levels and histopathological features of dysplasia in oral leukoplakia publication-title: J Oral Pathol Med doi: 10.1111/jop.12112 – volume: 8 year: 2013 ident: 10.1016/j.oraloncology.2020.104909_b0165 article-title: Expression, tissue distribution and function of miR-21 in esophageal squamous cell carcinoma publication-title: PLoS ONE doi: 10.1371/journal.pone.0073009 – volume: 17 start-page: 5441 year: 2019 ident: 10.1016/j.oraloncology.2020.104909_b0170 article-title: miRNA-10a promotes cancer cell proliferation in oral squamous cell carcinoma by upregulating GLUT1 and promoting glucose metabolism publication-title: Oncol Lett – volume: 17 start-page: 103 year: 2019 ident: 10.1016/j.oraloncology.2020.104909_b0110 article-title: Crosstalk between tumor cells and lymphocytes modulates heparanase expression publication-title: J Transl Med doi: 10.1186/s12967-019-1853-z – volume: 52 start-page: 505 year: 2016 ident: 10.1016/j.oraloncology.2020.104909_b0135 article-title: Expression of microRNA-133 inhibits epithelial-mesenchymal transition in lung cancer cells by directly targeting FOXQ1 publication-title: Arch Bronconeumol doi: 10.1016/j.arbres.2015.10.016 – volume: 15 start-page: 28 year: 2016 ident: 10.1016/j.oraloncology.2020.104909_b0180 article-title: Oral squamous cell carcinoma: microRNA expression profiling and integrative analyses for elucidation of tumourigenesis mechanism publication-title: Mol Cancer doi: 10.1186/s12943-016-0512-8 – volume: 41 start-page: 3499 year: 2019 ident: 10.1016/j.oraloncology.2020.104909_b0175 article-title: MicroRNA expression patterns in oral squamous cell carcinoma: hsa-mir-99b-3p and hsa-mir-100-5p as novel prognostic markers for oral cancer publication-title: Head Neck doi: 10.1002/hed.25866 – volume: 3 start-page: 1 year: 2019 ident: 10.1016/j.oraloncology.2020.104909_b0065 article-title: Small molecule inhibition of matrix metalloproteinases as a potential therapeutic for metastatic activity in squamous cell carcinoma publication-title: Oral Cancer doi: 10.1007/s41548-019-00017-7 – volume: 16 start-page: 148 year: 2017 ident: 10.1016/j.oraloncology.2020.104909_b0115 article-title: Exosomal miRNAs and miRNA dysregulation in cancer-associated fibroblasts publication-title: Mol Cancer doi: 10.1186/s12943-017-0718-4 – volume: 137 start-page: 200 year: 2013 ident: 10.1016/j.oraloncology.2020.104909_b0075 article-title: Tumor stroma as targets for cancer therapy publication-title: Pharmacol Ther doi: 10.1016/j.pharmthera.2012.10.003 – volume: 62 start-page: 113 year: 2017 ident: 10.1016/j.oraloncology.2020.104909_b0140 article-title: Dual-receptor (EGFR and c-MET) inhibition by tumor-suppressive miR-1 and miR-206 in head and neck squamous cell carcinoma publication-title: J Hum Genet doi: 10.1038/jhg.2016.47 – volume: 9 year: 2014 ident: 10.1016/j.oraloncology.2020.104909_b0155 article-title: MiR-21 expression in the tumor stroma of oral squamous cell carcinoma: an independent biomarker of disease free survival publication-title: PLoS ONE doi: 10.1371/journal.pone.0095193 – volume: 28 start-page: 5369 year: 2008 ident: 10.1016/j.oraloncology.2020.104909_b0160 article-title: MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators publication-title: Mol Cell Biol doi: 10.1128/MCB.00479-08 – volume: 7 year: 2016 ident: 10.1016/j.oraloncology.2020.104909_b0120 article-title: Exosome-mediated delivery of miR-9 induces cancer-associated fibroblast-like properties in human breast fibroblasts publication-title: Cell Death Dis doi: 10.1038/cddis.2016.224 – volume: 118 start-page: 209 year: 2014 ident: 10.1016/j.oraloncology.2020.104909_b0025 article-title: Tumor thickness as a predictive factor of lymph node metastasis and disease recurrence in T1N0 and T2N0 squamous cell carcinoma of the oral tongue publication-title: Oral Surg Oral Med Oral Pathol Oral Radiol doi: 10.1016/j.oooo.2014.03.023 – volume: 18 start-page: 2484 year: 2019 ident: 10.1016/j.oraloncology.2020.104909_b0095 article-title: Cancer associated fibroblasts are distinguishable from peri-tumor fibroblasts by biological characteristics in TSCC publication-title: Oncol Lett – volume: 119 start-page: 338 year: 2018 ident: 10.1016/j.oraloncology.2020.104909_b0125 article-title: MiR-133a-3p inhibits oral squamous cell carcinoma (OSCC) proliferation and invasion by suppressing COL1A1 publication-title: J Cell Biochem doi: 10.1002/jcb.26182 – volume: 24 start-page: 929 year: 2019 ident: 10.1016/j.oraloncology.2020.104909_b0130 article-title: MicroRNA-133 inhibits the growth and metastasis of the human lung cancer cells by targeting epidermal growth factor receptor publication-title: J BUON – volume: 8 start-page: 924 year: 2017 ident: 10.1016/j.oraloncology.2020.104909_b0085 article-title: Cancer-associated fibroblasts induce metalloprotease-independent cancer cell invasion of the basement membrane publication-title: Nat Commun doi: 10.1038/s41467-017-00985-8 – volume: 23 start-page: 633 year: 2011 ident: 10.1016/j.oraloncology.2020.104909_b0005 article-title: Epidemiology of cancer from the oral cavity and oropharynx publication-title: Eur J Gastroenterol Hepatol doi: 10.1097/MEG.0b013e3283484795 – volume: 96 start-page: 427 year: 2015 ident: 10.1016/j.oraloncology.2020.104909_b0145 article-title: miR-1, regulated by LMP1, suppresses tumour growth and metastasis by targeting K-ras in nasopharyngeal carcinoma publication-title: Int J Exp Pathol doi: 10.1111/iep.12162 |
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| Snippet | •There is interaction between miRNAs and the extracellular matrix in OSCC.•miR-1-3p, miR-133a-3 and miR-21-5p are involved in the process of OSCC... Highlights•There is interaction between miRNAs and the extracellular matrix in OSCC. •miR-1-3p, miR-133a-3 and miR-21-5p are involved in the process of OSCC... The objective of the present study was to evaluate the role of microRNA-mediated remodeling of the extracellular matrix in the process of tumor invasion of... |
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| SubjectTerms | Carcinogenesis Carcinoma, squamous cell Hematology, Oncology, and Palliative Medicine microRNAs Mouth Neoplasm invasiveness Otolaryngology |
| Title | Cancer-associated fibroblast regulation by microRNAs promotes invasion of oral squamous cell carcinoma |
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