Review of Dextromethorphan Administration in 18 Patients With Subacute Methotrexate Central Nervous System Toxicity

• Published in: Pediatric neurology Vol. 50; no. 6; pp. 625 - 629
• Main Authors: Afshar, Maryam, MD, Birnbaum, Daniel, MD, Golden, Carla, MD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2014
• Subjects: Central Nervous System Agents - therapeutic use; Child; dextromethorphan; Dextromethorphan - therapeutic use; Excitatory Amino Acid Antagonists - therapeutic use; homocysteine; Humans; Methotrexate - toxicity; methotrexate CNS toxicity; Neurology; Neurotoxicity Syndromes - drug therapy; Neurotoxicity Syndromes - physiopathology; NMDA receptor; Pediatrics; Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors; homocysteine; methotrexate CNS toxicity; NMDA receptor; dextromethorphan

Abstract Background The pathogenesis of methotrexate central nervous system toxicity is multifactorial, but it is likely related to central nervous system folate homeostasis. The use of folinate rescue has been described to decrease toxicity in patients who had received intrathecal methotrexate. It...