DNA replication stress and mitotic catastrophe mediate sotorasib addiction in KRASG12C-mutant cancer - Chiou, Li-Wen; Chan, Chien-Hui; Jhuang, Yu-Ling; Yang, Ching-Yao; Jeng, Yung-Ming (Journal of biomedical science, 2023)
Keywords: Addictions; Analysis; Annexin V; Apoptosis; Bioassays; Cancer; Cancer therapies; Care and treatment; Caspase; Cell culture; Cell cycle; Cell growth; Cell viability; Clinical trials; Comet assay; Cyclin-dependent kinase inhibitor p21; Damage; Deoxyribonucleic acid; DNA; DNA biosynthesis; DNA damage; DNA replication; Drug addiction; Drug approval; Drug resistance; Drug withdrawal; Flow cytometry; Genetic aspects; Growth factors; Health aspects; Hyperactivity; Immunofluorescence; Iodides; Kinases; KRAS; Lung cancer; Lung cancer, Non-small cell; MAP kinase; Mitosis; Mitotic catastrophe; Mutants; Non-small cell lung carcinoma; Pancreatic cancer; Propidium iodide; Protein kinases; Proteins; Replication; Replication stress; Sarcoma; Scientific equipment and supplies industry; Small cell lung carcinoma; Sotorasib; Substance abuse; Tumor cell lines; Withdrawal; Xenotransplantation; United States; United States--US; Taiwan