Localization and expression of CTP: Phosphocholine cytidylyltransferase in rat brain following cocaine exposure

• Published in: Journal of chemical neuroanatomy Vol. 96; pp. 1 - 6
• Main Authors: Pati, Sumitra, Ingram, Lishann M., Sun, Min K., Wagner, John J., Cummings, Brian S.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2019
• Subjects: Animals; Brain - drug effects; Brain - enzymology; Cerebellum; Choline-Phosphate Cytidylyltransferase - drug effects; Choline-Phosphate Cytidylyltransferase - metabolism; Cocaine; Cocaine - pharmacology; Dopamine Uptake Inhibitors - pharmacology; Hippocampus; Male; Phosphatidylcholine cytidylyltransferase; Rats; Rats, Sprague-Dawley; Cerebellum; CCTβ; CCTα; DAB; IHC; PUFA; MALDI; DAG; ROI; BSA; PC; NLS; CCT; OD; Cocaine; CTP; Hippocampus; Phosphatidylcholine cytidylyltransferase

•CCTβ, but not CCTα, expression was demonstrated in the rat hippocampus and cerebellum.•CCTβ cellular localization was region-specific, with cytosolic expression detected in Purkinje cells.•Nuclear expression of CCTb was detected in the hippocampus and midbrain.•CCTβ expression was not significantly...