Indirubin Inhibits LPS-Induced Inflammation via TLR4 Abrogation Mediated by the NF-kB and MAPK Signaling Pathways

• Published in: Inflammation Vol. 40; no. 1; pp. 1 - 12
• Main Authors: Lai, Jin-lun, Liu, Yu-hui, Liu, Chang, Qi, Ming-pu, Liu, Rui-ning, Zhu, Xi-fang, Zhou, Qiu-ge, Chen, Ying-yu, Guo, Ai-zhen, Hu, Chang-min
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.02.2017; Springer Nature B.V
• Subjects: Animals; Biomedical and Life Sciences; Biomedicine; Cytokines - drug effects; Cytokines - metabolism; Dose-Response Relationship, Drug; Female; Immunology; Indoles - pharmacology; Indoles - therapeutic use; Inflammation - drug therapy; Inflammation Mediators - metabolism; Internal Medicine; Lipopolysaccharides; MAP Kinase Signaling System - drug effects; Mastitis - drug therapy; Mice; NF-kappa B - metabolism; Original Article; Pathology; Pharmacology/Toxicology; Rheumatology; Signal Transduction - drug effects; Toll-Like Receptor 4 - physiology; indirubin; lipopolysaccharide (LPS); MAPK; inflammation; TLR4; NF-kB

Indirubin plays an important role in the treatment of many chronic diseases and exhibits strong anti-inflammatory activity. However, the molecular mode of action during mastitis prophylaxis remains poorly understood. In this study, a lipopolysaccharide (LPS)-induced mastitis mouse model showed that...