A Meta-Analysis of Reference Markers of Bone Turnover for Prediction of Fracture

• Published in: Calcified tissue international Vol. 94; no. 5; pp. 560 - 567
• Main Authors: Johansson, Helena, Odén, Anders, Kanis, John A., McCloskey, Eugene V., Morris, Howard A., Cooper, Cyrus, Vasikaran, Samuel
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.05.2014; Springer Nature B.V
• Subjects: Biochemistry; Biomarkers - blood; Biomedical and Life Sciences; Bone Remodeling - physiology; Cell Biology; Collagen; Endocrinology; Fractures; Fractures, Bone - blood; Humans; Life Sciences; Meta-analysis; Original Research; Orthopedics; Risk Factors; Marker of bone turnover; Fracture; Serum procollagen type I N propeptide; Serum carboxy-terminal cross-linking telopeptide of type I collagen; Meta-analysis

The aim of this report was to summarize the clinical performance of two reference bone turnover markers (BTMs) in the prediction of fracture risk. We used an updated systematic review to examine the performance characteristics of serum procollagen type I N propeptide (s-PINP) and serum C-terminal cr...