Aluminum is a weak agonist for the calcium-sensing receptor

• Published in: Kidney international Vol. 55; no. 5; pp. 1750 - 1758
• Main Authors: Spurney, Robert F., Pi, Min, Flannery, Patrick, Quarles, L. Darryl
• Format: Journal Article Conference Proceeding
• Language: English
• Published: New York, NY Elsevier Inc 01.05.1999; Nature Publishing
• Subjects: agonist; Aluminum - pharmacology; Animals; Biological and medical sciences; Calcium - analysis; Calcium - pharmacology; cations; Cells, Cultured; Cytosol - chemistry; end-stage renal disease; Fundamental and applied biological sciences. Psychology; g-protein coupled receptors; Gadolinium - pharmacology; Gene Expression - physiology; human embryonic kidney cells; Humans; Inositol Phosphates - biosynthesis; intracellular calcium; Ionomycin - pharmacology; Ionophores - pharmacology; Kidney - cytology; Magnesium - pharmacology; Neomycin - pharmacology; Protein Synthesis Inhibitors - pharmacology; Rats; Receptors, Calcium-Sensing; Receptors, Cell Surface - agonists; Receptors, Cell Surface - genetics; Signal Transduction - drug effects; Transfection; Vertebrates: urinary system; cations; agonist; intracellular calcium; end-stage renal disease; human embryonic kidney cells; g-protein coupled receptors; Cell culture; Agonist; Rat; Rodentia; Transgenic animal; Cell biology; Experimental study; In vitro; Kidney; Vertebrata; Membrane receptor; Mammalia; Urinary system; Aluminium ion; Physiology; Biological effect

Aluminum is a weak agonist for the calcium-sensing receptor. Aluminum (Al3+) has diverse biological effects mediated through activation of a putative extracellular cation-sensing receptor. A recently identified calcium-sensing receptor (CaSR), which has been identified in target tissues for Al3+, ma...