Uncommon patterns of antinuclear antibodies recognizing mitotic spindle apparatus antigens and clinical associations

• Published in: Medicine (Baltimore) Vol. 97; no. 34; p. e11727
• Main Authors: Betancur, Juan Felipe, Londoño, Adriana, Estrada, Victoria Eugenia, Puerta, Sandra Liliana, Osorno, Sandra Marcela, Loaiza, Angela, Carmona, Jenny Andrea, Gómez-Puerta, José Alfredo
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer Health 01.08.2018
• Subjects: Adult; Aged; Antibodies, Antinuclear - metabolism; Autoantigens - immunology; Colombia; Female; Humans; Male; Middle Aged; Observational Study; Retrospective Studies; Rheumatic Diseases - classification; Rheumatic Diseases - immunology; Spindle Apparatus - immunology

Antinuclear antibodies (ANA) are key biomarkers in the evaluation of rheumatic diseases. The prevalence and clinical significance of uncommon or rare patterns, particularly those directed at the mitotic spindle apparatus (MSA), are not well understood. We aimed to investigate the prevalence and clin...