Anti-SARS-CoV-2 IgG antibody response among Indian COVID-19 patients using β-propiolactone-inactivated, whole virus-based indirect ELISA

• Published in: Journal of virological methods Vol. 287; p. 113996
• Main Authors: Kulkarni, Ruta, Patil, Harshad P., Palkar, Sonali, Lalwani, Sanjay, Mishra, Akhilesh Chandra, Arankalle, Vidya
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2021
• Subjects: Antibodies, Viral - blood; Antibody; COVID-19; COVID-19 - blood; COVID-19 - diagnosis; COVID-19 - pathology; COVID-19 Serological Testing - methods; ELISA; Enzyme-Linked Immunosorbent Assay; Humans; IgG; Immunoglobulin G - blood; Inactivated virus; Propiolactone - pharmacology; SARS-CoV-2; SARS-CoV-2 - immunology; Sensitivity and Specificity; Seroepidemiologic Studies; Virus Inactivation - drug effects; COVID-19; IgG; SARS-CoV-2; Inactivated virus; Antibody; ELISA

•Development of indirect IgG ELISA using β-propiolactone-inactivated SARS-CoV-2.•Detection of anti-SARS-CoV-2 IgG during early disease phase.•Higher IgG seropositivity and OD values in COVID-19 patients with severe disease. Coronavirus disease 2019 (COVID-19) pandemic caused by infection with severe...