3,5-Dimethyl-2,4,6-trimethoxychalcone Lessens Obesity and MAFLD in Leptin-Deficient ob/ob Mice

• Published in: International journal of molecular sciences Vol. 25; no. 18; p. 9838
• Main Authors: Gaigé, Stéphanie, Abysique, Anne, Barbouche, Rym, Tonetto, Alain, Di Maio, Attilio, Robin, Maxime, Lormier, Anh-Tuan, Troadec, Jean-Denis
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 11.09.2024; MDPI
• Subjects: Animals; Anti-Obesity Agents - chemistry; Anti-Obesity Agents - pharmacology; Body mass index; Causes of; Chalcones - chemistry; Chalcones - pharmacology; Development and progression; Diet therapy; Eating - drug effects; Fatty acids; Fatty liver; Food; Glucose; Health aspects; Hypothalamus; Leptin; Leptin - metabolism; Life Sciences; Liver - drug effects; Liver - metabolism; Liver diseases; Male; Metabolism; Mice; Mice, Inbred C57BL; Mice, Obese; Mutation; Obesity; Obesity - drug therapy; Obesity - metabolism; Overweight; Physiological aspects; Polyphenols; Public health; France; chalcone; liver; brainstem; leptin; steatosis; hypothalamus; food intake

Chalcones constitute an important group of natural compounds abundant in fruits and comestible plants. They are a subject of increasing interest because of their biological activities, including anti-diabetic and anti-obesity effects. The simple chalcone structural scaffold can be modified at multip...