MLL5 (KMT2E): structure, function, and clinical relevance

• Published in: Cellular and molecular life sciences : CMLS Vol. 74; no. 13; pp. 2333 - 2344
• Main Authors: Zhang, Xiaoming, Novera, Wisna, Zhang, Yan, Deng, Lih-Wen
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.07.2017; Springer Nature B.V
• Subjects: Animals; Biochemistry; Biological activity; Biomedical and Life Sciences; Biomedicine; Cell Biology; Cell Cycle; Clinical trials; Disease; DNA-Binding Proteins - chemistry; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Embryogenesis; Embryonic growth stage; Enrichment; Evolution; Gene expression; Gene regulation; Genes; Genomic Instability; Hematopoiesis; Histone methyltransferase; Homology; Humans; Isoforms; Leukemia; Life Sciences; Lysine; Maintenance; Mutation - genetics; N-Methyltransferase; Protein Isoforms - chemistry; Protein Isoforms - genetics; Protein Isoforms - metabolism; Proteins; Review; Reviews; Spermatogenesis; Stability; Structure-function relationships; Substrates; Transcription; Cell division; Hematopoietic stem cell differentiation; Histone methylation; Leukemia; PHD finger; Cancer

The mixed lineage leukemia (MLL) family of genes, also known as the lysine N-methyltransferase 2 (KMT2) family, are homologous to the evolutionarily conserved trithorax group that plays critical roles in the regulation of homeotic gene (HOX) expression and embryonic development. MLL5, assigned as KM...