The Protein Expression of PDL1 Is Highly Correlated with Those of eIF2α and ATF4 in Lung Cancer

• Published in: Disease markers Vol. 2018; no. 2018; pp. 1 - 9
• Main Authors: Hua, Chung-Ching, Kuo, Wei-Ke, Chen, Tzu-Ping, Chang, Liang-Che
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2018; Hindawi; John Wiley & Sons, Inc
• Subjects: Activating transcription factor 4; Activating Transcription Factor 4 - genetics; Activating Transcription Factor 4 - metabolism; Adenocarcinoma; Apoptosis; B7-H1 Antigen - genetics; B7-H1 Antigen - metabolism; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Cancer; Cancer therapies; Carcinoma - genetics; Carcinoma - metabolism; Cellular stress response; Correlation; Endoplasmic reticulum; Eukaryotic Initiation Factor-2 - genetics; Eukaryotic Initiation Factor-2 - metabolism; Genes; Humans; Immune system; Immunoglobulins; Initiation factor eIF-2; Interferon; Interferon regulatory factor 1; Interferon regulatory factor 7; Lung cancer; Lung Neoplasms - genetics; Lung Neoplasms - metabolism; Lymphocytes; Mutation; PD-1 protein; Protein expression; Protein folding; Proteins; Squamous cell carcinoma; STAT Transcription Factors - genetics; STAT Transcription Factors - metabolism; Stat1 protein; Stat2 protein; Subgroups; Tissues; Transcription factors; Tumors; United States > US

Introduction. The expression of programmed death 1 (PD1) and programmed death ligand 1 (PDL1) can be induced by the interferon (IFN)/signal transducer and activator of transcription (STAT) pathway. The PD1/PDL1 reverse signaling can activate the eukaryotic translation initiation factor 2 (eIF2α)/act...