Neuroprotective Effect of HIIT against GFAP Hypertrophy through Mitochondrial Dynamics in APP/PS1 Mice

• Published in: Oxidative medicine and cellular longevity Vol. 2022; no. 1; p. 1764589
• Main Authors: Liu, Qianqian, Fu, Xiaonan, Han, Rui, Liu, Xuefeng, Zhao, Xiantao, Wei, Jianshe
• Format: Journal Article
• Language: English
• Published: United States Hindawi 2022; John Wiley & Sons, Inc
• Subjects: Alzheimer Disease - metabolism; Alzheimer Disease - psychology; Alzheimer Disease - therapy; Alzheimer's disease; Animal cognition; Animals; Antibodies; Astrocytes - metabolism; Astrocytes - pathology; Case-Control Studies; Cognition; Cognitive Dysfunction - therapy; Disease Models, Animal; Drinking water; Ethanol; Exercise; Exercise Therapy - methods; Exploratory Behavior; Glial Fibrillary Acidic Protein - metabolism; High-Intensity Interval Training - methods; Hippocampus - metabolism; Hypertrophy; Interval training; Intervention; Laboratory animals; Male; Mice; Mice, Inbred C57BL; Mitochondrial Dynamics; Neurons - metabolism; Neuroprotection; Pathogenesis; Physical Conditioning, Animal - methods; Physical fitness; Proteins; Rest; Signal Transduction; Treatment Outcome; Beijing China; China

Alzheimer’s disease (AD) is characterized by the accumulation of β-amyloid (Aβ) plaques and tau neurofibrillary tangles in the brain. Although the exact details of the neuronal protective effect of high-intensity interval training (HIIT) on AD remain unclear, the preclinical phase of AD appears to b...