Olfactory bulb α-synucleinopathy has high specificity and sensitivity for Lewy body disorders

• Published in: Acta neuropathologica Vol. 117; no. 2; pp. 169 - 174
• Main Authors: Beach, Thomas G., White, Charles L., Hladik, Christa L., Sabbagh, Marwan N., Connor, Donald J., Shill, Holly A., Sue, Lucia I., Sasse, Jeanne, Bachalakuri, Jyothi, Henry-Watson, Jonette, Akiyama, Haru, Adler, Charles H.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.02.2009
• Subjects: Aged; Aged, 80 and over; alpha-Synuclein - analysis; Alzheimer Disease - diagnosis; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Brain - pathology; Brain Chemistry; Female; Humans; Immunohistochemistry; Lewy Body Disease - diagnosis; Lewy Body Disease - metabolism; Lewy Body Disease - pathology; Logistic Models; Male; Medicine; Medicine & Public Health; Middle Aged; Neuropsychological Tests; Neurosciences; Olfactory Bulb - chemistry; Olfactory Bulb - pathology; Original Paper; Parkinson Disease - diagnosis; Parkinson Disease - metabolism; Parkinson Disease - pathology; Pathology; Sensitivity and Specificity; Parkinson’s disease, surgery; Deep brain stimulation; Biopsy; Olfactory bulb; Transplantation; Gene therapy; Dementia with Lewy bodies, diagnosis, therapy, clinical trial; α-Synuclein, Lewy bodies, incidental Lewy body disease

Involvement of the olfactory bulb by Lewy-type α-synucleinopathy (LTS) is known to occur at an early stage of Parkinson’s disease (PD) and Lewy body disorders and is therefore of potential usefulness diagnostically. An accurate estimate of the specificity and sensitivity of this change has not previ...