Evaluation of [18F]-JNJ-64326067-AAA tau PET tracer in humans

• Published in: Journal of cerebral blood flow and metabolism Vol. 41; no. 12; pp. 3302 - 3313
• Main Authors: Baker, Suzanne L, Provost, Karine, Thomas, Wesley, Whitman, AJ, Janabi, Mustafa, Schmidt, Mark E, Timmers, Maarten, Kolb, Hartmuth C, Rabinovici, Gil D, Jagust, William J
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.12.2021
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - diagnostic imaging; Alzheimer Disease - metabolism; Brain - diagnostic imaging; Brain - metabolism; Female; Fluorine Radioisotopes - administration & dosage; Humans; Isoquinolines - administration & dosage; Male; Original; Positron-Emission Tomography; Pyridines - administration & dosage; Radiopharmaceuticals - administration & dosage; tau Proteins - metabolism; Aging; tau; Alzheimer’s disease; [18F]-JNJ-067; PET

The [18F]-JNJ-64326067-AAA ([18F]-JNJ-067) tau tracer was evaluated in healthy older controls (HCs), mild cognitive impairment (MCI), Alzheimer’s disease (AD), and progressive supranuclear palsy (PSP) participants. Seventeen subjects (4 HCs, 5 MCIs, 5 ADs, and 3 PSPs) received a [11C]-PIB amyloid PE...