Synthesis and evaluation of debromohymenialdisine-derived Chk2 inhibitors - Saleem, Rahman Shah Zaib; Lansdell, Theresa A.; Tepe, Jetze J. (Bioorganic & medicinal chemistry, 2012)
Keywords: Animals; antagonists & inhibitors; Azepines; Azepines - chemical synthesis; Azepines - chemistry; Azepines - pharmacology; Binding Sites; Biological and medical sciences; Checkpoint Kinase 1; Checkpoint Kinase 2; Checkpoint kinases; chemical synthesis; chemistry; Chk2; Crystallography, X-Ray; Debromohymenialdisine; drug effects; drugs; Enzyme Activation; Enzyme Activation - drug effects; Hymenialdisine; Inhibitory Concentration 50; Medical sciences; metabolism; metabolites; Molecular Structure; Natural products; pharmacology; Pharmacology. Drug treatments; Porifera; Porifera - chemistry; Protein Kinase Inhibitors; Protein Kinase Inhibitors - chemical synthesis; Protein Kinase Inhibitors - pharmacology; Protein Kinases; Protein Kinases - metabolism; Protein Serine-Threonine Kinases; Protein-Serine-Threonine Kinases - antagonists & inhibitors; Pyrroles; Pyrroles - chemical synthesis; Pyrroles - chemistry; Pyrroles - pharmacology; Radioprotection; Substrate Specificity; Hymenialdisine; Debromohymenialdisine; Checkpoint kinases; Chk2; Natural products; Radioprotection; Evaluation; Enzyme; Transferases; Non-specific serine/threonine protein kinase; Chemical structure; Natural compound; Signal transduction; Alkaloid; Kinase; Inhibitor; Chemical synthesis