Comparison of an established antibody sandwich method with an inhibition method of Histoplasma capsulatum antigen detection

• Published in: Journal of clinical microbiology Vol. 38; no. 8; pp. 2909 - 2913
• Main Authors: GARRINGER, T. O, WHEAT, L. J, BRIZENDINE, E. J
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.08.2000
• Subjects: Antibodies, Fungal - immunology; Antigens, Fungal - analysis; Antigens, Fungal - blood; Antigens, Fungal - urine; Biological and medical sciences; Blastomyces dermatitidis; Cross Reactions; Histoplasma - immunology; Histoplasma - isolation & purification; Histoplasma capsulatum; Histoplasmoses; Histoplasmosis - diagnosis; Histoplasmosis - microbiology; Human mycoses; Humans; Immunoenzyme Techniques - methods; Immunoenzyme Techniques - standards; Infectious diseases; Medical sciences; Mycology; Mycoses; Paracoccidioides brasiliensis; Reproducibility of Results; Sensitivity and Specificity; Tropical mycoses; Performance evaluation; Human; Urine; Histoplasmosis; Mycosis; Histoplasma capsulatum; Enzyme immunoassay; Fungi; Infection; Antigen; Serum; Fungi Imperfecti; Diagnosis; Inhibition; Detection; Thallophyta

The Histoplasma antigen immunoassay utilizes an antibody sandwich method that provides a rapid and reliable means of diagnosing the more severe forms of histoplasmosis. Inhibition assays have been developed for antigen detection and offer at least one potential advantage, namely, reduced antibody re...