Neutrophils and Circulating Inflammatory Biomarkers in Diabetes Mellitus and Heart Failure With Preserved Ejection Fraction

• Published in: The American journal of cardiology Vol. 178; pp. 80 - 88
• Main Authors: Chaar, Diana, Dumont, Benjamin L., Vulesevic, Branka, Neagoe, Paul-Eduard, Räkel, Agnès, White, Michel, Sirois, Martin G.
• Format: Journal Article
• Language: English
• Published: New York Elsevier Inc 01.09.2022; Elsevier Limited
• Subjects: Biomarkers; Blood; C-reactive protein; Cardiovascular disease; Cell adhesion; Cell adhesion molecules; Congestive heart failure; Cytokines; Cytotoxicity; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); E-selectin; Ejection fraction; Enzyme-linked immunosorbent assay; Growth factors; Heart failure; Hemoglobin; Hypertension; Inflammation; Intercellular adhesion molecule 1; Interleukin 1; Interleukin 1 receptor antagonist; Interleukin 6; Interleukin 8; Interleukins; Laboratories; Leukocytes (neutrophilic); Lipopolysaccharides; Lymphocytes T; Neutrophils; Nitric oxide; Plasma; Receptors; Tumor necrosis factor-TNF; Values; Variance analysis; Vascular cell adhesion molecule 1; Vascular endothelial growth factor; New York; United States > US

Heart failure with preserved ejection fraction (HFpEF) is characterized by low-grade chronic inflammation, which could be exacerbated by type 2 diabetes mellitus (DM). We hypothesized that neutrophils in patients with DM and patients with HFpEF with/without DM contribute to low-grade inflammation th...