Molecular Imaging of Cancer with Nanoparticle-Based Theranostic Probes
Although advancements in medical technology supporting cancer diagnosis and treatment have improved survival, these technologies still have limitations. Recently, the application of noninvasive imaging for cancer diagnosis and therapy has become an indispensable component in clinical practice. Howev...
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| Published in | Contrast media and molecular imaging Vol. 2017; no. 2017; pp. 1 - 11 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Cairo, Egypt
Hindawi Publishing Corporation
01.01.2017
Hindawi Hindawi Limited |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Although advancements in medical technology supporting cancer diagnosis and treatment have improved survival, these technologies still have limitations. Recently, the application of noninvasive imaging for cancer diagnosis and therapy has become an indispensable component in clinical practice. However, current imaging contrasts and tracers, which are in widespread clinical use, have their intrinsic limitations and disadvantages. Nanotechnologies, which have improved in vivo detection and enhanced targeting efficiency for cancer, may overcome some of the limitations of cancer diagnosis and therapy. Theranostic nanoparticles have great potential as a therapeutic model, which possesses the ability of their nanoplatforms to load targeted molecule for both imaging and therapeutic functions. The resulting nanosystem will likely be critical with the growth of personalized medicine because of their diagnostic potential, effectiveness as a drug delivery vehicle, and ability to oversee patient response to therapy. In this review, we discuss the achievements of modern nanoparticles with the goal of accurate tumor imaging and effective treatment and discuss the future prospects. |
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| AbstractList | Although advancements in medical technology supporting cancer diagnosis and treatment have improved survival, these technologies still have limitations. Recently, the application of noninvasive imaging for cancer diagnosis and therapy has become an indispensable component in clinical practice. However, current imaging contrasts and tracers, which are in widespread clinical use, have their intrinsic limitations and disadvantages. Nanotechnologies, which have improved in vivo detection and enhanced targeting efficiency for cancer, may overcome some of the limitations of cancer diagnosis and therapy. Theranostic nanoparticles have great potential as a therapeutic model, which possesses the ability of their nanoplatforms to load targeted molecule for both imaging and therapeutic functions. The resulting nanosystem will likely be critical with the growth of personalized medicine because of their diagnostic potential, effectiveness as a drug delivery vehicle, and ability to oversee patient response to therapy. In this review, we discuss the achievements of modern nanoparticles with the goal of accurate tumor imaging and effective treatment and discuss the future prospects. |
| Author | Ma, Ying-Yu Mou, Xiao-Zhou Wang, Hui-Ju Huang, Dongsheng Tong, Xiang-Min Wang, Shi-Bing Jin, Ke-Tao |
| AuthorAffiliation | 3 Department of Gastrointestinal Surgery, Shaoxing People's Hospital, Shaoxing Hospital of Zhejiang University, Shaoxing 312000, China 1 Clinical Research Institute, Zhejiang Provincial People's Hospital, Hangzhou 310014, China 4 School of Basic Medical Sciences, Hangzhou Medical College, Hangzhou 310053, China 2 Key Laboratory of Cancer Molecular Diagnosis and Individualized Therapy of Zhejiang Province, Hangzhou 310014, China |
| AuthorAffiliation_xml | – name: 3 Department of Gastrointestinal Surgery, Shaoxing People's Hospital, Shaoxing Hospital of Zhejiang University, Shaoxing 312000, China – name: 4 School of Basic Medical Sciences, Hangzhou Medical College, Hangzhou 310053, China – name: 1 Clinical Research Institute, Zhejiang Provincial People's Hospital, Hangzhou 310014, China – name: 2 Key Laboratory of Cancer Molecular Diagnosis and Individualized Therapy of Zhejiang Province, Hangzhou 310014, China |
| Author_xml | – sequence: 1 fullname: Mou, Xiao-Zhou – sequence: 2 fullname: Tong, Xiang-Min – sequence: 3 fullname: Wang, Hui-Ju – sequence: 4 fullname: Wang, Shi-Bing – sequence: 5 fullname: Jin, Ke-Tao – sequence: 6 fullname: Ma, Ying-Yu – sequence: 7 fullname: Huang, Dongsheng |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29097909$$D View this record in MEDLINE/PubMed |
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| ContentType | Journal Article |
| Copyright | Copyright © 2017 Ying-Yu Ma et al. Copyright © 2017 Ying-Yu Ma et al.; This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2017 Ying-Yu Ma et al. 2017 |
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| SubjectTerms | Biocompatibility Biomedical materials Breast cancer Cancer Contrast agents Diagnosis Diagnostic systems Drug delivery Drug delivery systems Gene therapy Humans Imaging Kinases Medical diagnosis Medical imaging Medical technology Molecular Imaging - methods Nanoparticles Nanoparticles - therapeutic use Neoplasms - diagnostic imaging NMR Nuclear magnetic resonance Precision medicine Review Theranostic Nanomedicine - methods Therapy Tracers Tumors |
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| Title | Molecular Imaging of Cancer with Nanoparticle-Based Theranostic Probes |
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