Mitochondrial dynamics and mitochondrial quality control

Mitochondria are cellular energy powerhouses that play important roles in maintaining cell survival, cell death and cellular metabolic homeostasis. Timely removal of damaged mitochondria via autophagy (mitophagy) is thus critical for cellular homeostasis and function. Mitochondria are reticular orga...

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Published inRedox biology Vol. 4; no. C; pp. 6 - 13
Main Authors Ni, Hong-Min, Williams, Jessica A., Ding, Wen-Xing
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier 01.04.2015
Subjects
Animals
Autophagy
Cytoskeleton - genetics
Graphical Review
Homeostasis
Humans
Lysosomes - metabolism
Mammals
Mitochondria - genetics
Mitochondria - metabolism
Mitochondrial Degradation - genetics
Mitochondrial Dynamics - genetics
Mitochondrial spheroids
Mitophagy
Parkin
Mitophagy
Mitochondrial spheroids
Autophagy
Parkin
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Summary:Mitochondria are cellular energy powerhouses that play important roles in maintaining cell survival, cell death and cellular metabolic homeostasis. Timely removal of damaged mitochondria via autophagy (mitophagy) is thus critical for cellular homeostasis and function. Mitochondria are reticular organelles that have high plasticity for their dynamic structures and constantly undergo fission and fusion as well as movement through the cytoskeleton. In this review, we discuss the most recent progress on the molecular mechanisms and roles of mitochondrial fission/fusion and mitochondrial motility in mitophagy. We also discuss multiple pathways leading to the quality control of mitochondria in addition to the traditional mitophagy pathway under different conditions.
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ISSN:2213-2317
2213-2317
DOI:10.1016/j.redox.2014.11.006