Low status, humiliation, dopamine and risk of schizophrenia

• Published in: Psychological medicine Vol. 53; no. 3; pp. 609 - 613
• Main Authors: Selten, Jean Paul, Ormel, Johan
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.02.2023
• Subjects: Autonomy; Caudate-putamen; Corpus Striatum - metabolism; Dopamine; Dopamine D2 receptors; Dopamine D3 receptors; Economic status; Humans; Humiliation; Hypotheses; Mental disorders; Mesencephalon; Neostriatum; Neurons; Psychosis; Receptors, Dopamine D3 - metabolism; Risk factors; Schizophrenia; Schizophrenia - epidemiology; Schizophrenia - etiology; Self esteem; Self evaluation; Social interactions; Social participation; Socioeconomic factors; Socioeconomic status; Europe

The social defeat hypothesis of schizophrenia, which proposes that the chronic experience of outsider status or subordinate position leads to increased striatal dopamine activity and thereby to increased risk, has been criticized. The aims of this paper are to improve the definition of defeat and to...