Rhinacanthin C Alleviates Amyloid-β Fibrils’ Toxicity on Neurons and Attenuates Neuroinflammation Triggered by LPS, Amyloid-β, and Interferon-γ in Glial Cells

• Published in: Oxidative medicine and cellular longevity Vol. 2017; no. 2017; pp. 1 - 18
• Main Authors: Wen, Shu-Fang, Perng, Ming-Der, Pan, I-Horng, Lu, I-Huang, Chang, Chih-Hsuan, Lin, Ni-Hsuan, Li, Ming-Han, Chuang, Kai-An, Takahashi, Tomoya
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2017; Hindawi; John Wiley & Sons, Inc
• Subjects: Alzheimer's disease; Apoptosis; Brain research; Kinases; Neurons; Neurosciences; Penicillin; R&D; Research & development; Rodents; Toxicity; Tuberculosis; Tumor necrosis factor-TNF; Taiwan

Neuroinflammation plays a central role in the pathophysiology of Alzheimer’s disease (AD). Compounds that suppress neuroinflammation have been identified as potential therapeutic targets for AD. Rhinacanthin C (RC), a naphthoquinone ester found in Rhinacanthus nasutus Kurz (Acanthaceae), is currentl...