Sympathetic innervation of interscapular brown adipose tissue is not a predominant mediator of Oxytocin (OT)-elicited reductions of body weight gain and adiposity in male diet-induced obese rats

• Published in: Frontiers in Drug Delivery Vol. 4
• Main Authors: Edwards, Melise M., Nguyen, Ha K., Dodson, Andrew D., Herbertson, Adam J., Honeycutt, Mackenzie K., Slattery, Jared D., Rambousek, June R., Tsui, Edison, Wolden-Hanson, Tami, Wietecha, Tomasz A., Graham, James L., Tapia, Geronimo P., Sikkema, Carl L., O’Brien, Kevin D., Mundinger, Thomas O., Peskind, Elaine R., Ryu, Vitaly, Havel, Peter J., Khan, Arshad M., Taborsky, Gerald J., Blevins, James E.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 2024
• Subjects: Brown adipose tissue (BAT); obesity; oxytocin; sympathetic nervous system (SNS); white adipose tissue (WAT); Obesity; oxytocin; brown adipose tissue; white adipose tissue; sympathetic nervous system

Recent studies indicate that central administration of oxytocin (OT) reduces body weight (BW) in high fat diet-induced obese (DIO) rodents by reducing energy intake and increasing energy expenditure (EE). Previous studies in our lab have shown that administration of OT into the fourth ventricle (4V;...