Multivariate empirical mode decomposition reveals markers of Alzheimer’s Disease in the oscillatory response to transcranial magnetic stimulation

• Published in: Clinical neurophysiology Vol. 176; p. 2110756
• Main Authors: Bernardi, Davide, Casula, Elias P., Rocchi, Lorenzo, Fadiga, Luciano, Koch, Giacomo, Papo, David
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.08.2025
• Subjects: Alzheimer’s Disease; Brain oscillations; EEG; Multivariate empirical mode decomposition; Neurology; Transcranial magnetic stimulation; ADCS - ADL; NPPT; AD; IMF; Alzheimer’s Disease; Transcranial magnetic stimulation; DLPFC; EEG; FAB; NPI; MSO; MEMD; AM; MEG; CDR; ADAS - COG; SCD; Brain oscillations; MMSE; RMT; HC; TMS; Multivariate empirical mode decomposition; TEP; Intrinsic Mode Function; Neuropsychiatric Inventory; Clinical Dementia Rating; Electroencephalography; Transcranial Magnetic Stimulation; Frontal Assessment Battery; Non-parametric permutation test; Multivariate Empirical Mode Decomposition; Amplitude Modulation; Alzheimer’s Disease Assessment Scale - Cognitive Subscale; Scalp-to-cortex Distance; TMS-evoked potential; Magnetoencephalography; Healthy Control; Alzheimer’s Disease Cooperative Study - Activities of Daily Living; Maximum Stimulator Output; Resting Motor Threshold; Dorsolateral Prefrontal Cortex; Mini-Mental State Examination
• ISSN: 1388-2457; 1872-8952; 1872-8952
• DOI: 10.1016/j.clinph.2025.2110756

To investigate EEG activity following transcranial magnetic stimulation (TMS) of the dorsolateral prefrontal cortex of Alzheimer’s Disease (AD) patients and control subjects using a data-driven characterization of brain oscillatory activity without prescribed frequency bands. We employed multivariat...