New insights into the epigenetics of osteoporosis

• Published in: Genomics (San Diego, Calif.) Vol. 111; no. 4; pp. 793 - 798
• Main Authors: Letarouilly, Jean-Guillaume, Broux, Odile, Clabaut, Aline
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2019; Elsevier
• Subjects: Adipocyte; adipocytes; Animals; bone density; bone formation; bone marrow; bone resorption; Differentiation; DNA Methylation; Epigenesis, Genetic; Epigenetics; Histone Code; Human osteoporosis; Humans; Life Sciences; mesenchymal stromal cells; MicroRNAs - genetics; MicroRNAs - metabolism; Osteoblast; osteoblasts; Osteoclast; osteoclasts; osteoporosis; Osteoporosis - genetics; Epigenetics; Osteoblast; Adipocyte; Osteoclast; Human osteoporosis; Differentiation

Osteoporosis is characterized by reduced bone formation and accumulation of adipocytes in the bone marrow compartment. The decrease in bone mass results from an imbalance between osteoclast-mediated bone resorption and osteoblast-mediated bone formation. The deficiency of bone cells to replace the r...