Oxidative stress in Alzheimer disease: A possibility for prevention

• Published in: Neuropharmacology Vol. 59; no. 4; pp. 290 - 294
• Main Authors: Bonda, David J., Wang, Xinglong, Perry, George, Nunomura, Akihiko, Tabaton, Massimo, Zhu, Xiongwei, Smith, Mark A.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.09.2010
• Subjects: Alzheimer disease; Alzheimer Disease - metabolism; Alzheimer Disease - prevention & control; Alzheimer's disease; Animals; Antioxidants; Antioxidants - pharmacology; Antioxidants - therapeutic use; Coenzyme Q; Dimebon; Humans; Mitochondria - drug effects; Mitochondria - metabolism; Mitochondrial antioxidants; MitoQ; Oxidative stress; Oxidative Stress - drug effects; Oxidative Stress - physiology; Reactive oxidative species; Reactive Oxygen Species - antagonists & inhibitors; Reactive Oxygen Species - metabolism; Ubiquinone - metabolism; Antioxidants; Reactive oxidative species; Oxidative stress; MitoQ; Alzheimer disease; Mitochondrial antioxidants; Dimebon; Coenzyme Q

Oxidative stress is at the forefront of Alzheimer disease (AD) research. While its implications in the characteristic neurodegeneration of AD are vast, the most important aspect is that it seems increasingly apparent that oxidative stress is in fact a primary progenitor of the disease, and not merel...