The spindle-assembly checkpoint in space and time

• Published in: Nature reviews. Molecular cell biology Vol. 8; no. 5; pp. 379 - 393
• Main Authors: Musacchio, Andrea, Salmon, Edward D.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.05.2007; Nature Publishing Group
• Subjects: Aneuploidy; Animals; Biochemistry; Biomedical and Life Sciences; Cancer Research; Carcinogenesis; Cell Biology; Cell Cycle - physiology; Cell Cycle Proteins - metabolism; Cell Cycle Proteins - physiology; Chromosomes; Developmental Biology; Genes; Genes, cdc - physiology; Humans; Kinases; Kinetochores - physiology; Life Sciences; Microtubules; Mitosis; Models, Biological; Neoplasms - etiology; Neoplasms - genetics; Oncology; Phosphotransferases - physiology; Physiological aspects; Proteins; review-article; Safety devices; Spindle Apparatus - metabolism; Stem Cells; Time Factors; Italy

Key Points The spindle-assembly checkpoint (SAC) is a safety device that monitors the attachment of spindle microtubules to the surface of chromosome-associated structures called kinetochores. It is believed that the SAC senses the occupancy of microtubules at the surface of kinetochores, as well as...