Equilin displays similar endothelium-independent vasodilator potential to 17β-estradiol regardless of lower potential to inhibit calcium entry

• Published in: Steroids Vol. 141; pp. 46 - 54
• Main Authors: Filgueira, Fernando P., Lobato, Núbia S., Nascimento, Denise L., Ceravolo, Graziela S., Giachini, Fernanda R.C., Lima, Victor V., Dantas, Ana Paula, Fortes, Zuleica B., Webb, R. Clinton, Tostes, Rita C., Carvalho, Maria Helena C.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2019
• Subjects: 17β-Estradiol; Animals; Calcium - metabolism; Calcium channel; Endoplasmic Reticulum - drug effects; Endoplasmic Reticulum - metabolism; Equilin; Equilin - pharmacology; Estradiol - pharmacology; Female; Mesenteric arteries; Rats; Rats, Inbred SHR; Vasodilation - drug effects; Vasodilator Agents - pharmacology; Vasorelaxation; 17β-Estradiol; Equilin; Vasorelaxation; Calcium channel; Mesenteric arteries

[Display omitted] •Equilin, one of the major components of CEE, causes vasorelaxation.•Equilin relaxes rat mesenteric arteries in a concentration dependent manner.•Equilin blocks voltage dependent calcium channels.•Equilin relaxes resistance mesenteric arteries similarly to 17β-estradiol. Conjugated...