sGraSP: A graph-based method for the derivation of subject-specific functional parcellations of the brain

•We describe sGraSP, a novel subject-specific functional parcellation method.•sGraSP is tested using a large neurodevelopmental cohort (859 scans total).•Additional tests are generated by mixing subject and population signal.•sGraSP outperforms simpler approaches based on Voronoi tessellations.•Neur...

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Published inJournal of neuroscience methods Vol. 277; pp. 1 - 20
Main Authors Honnorat, N., Satterthwaite, T.D., Gur, R.E., Gur, R.C., Davatzikos, C.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.02.2017
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Abstract •We describe sGraSP, a novel subject-specific functional parcellation method.•sGraSP is tested using a large neurodevelopmental cohort (859 scans total).•Additional tests are generated by mixing subject and population signal.•sGraSP outperforms simpler approaches based on Voronoi tessellations.•Neurodevelopmental trends are robustly captured by sGraSP for all the signal mixing. Resting-state fMRI (rs-fMRI) has emerged as a prominent tool for the study of functional connectivity. The identification of the regions associated with the different brain functions has received significant interest. However, most of the studies conducted so far have focused on the definition of a common set of regions, valid for an entire population. The variation of the functional regions within a population has rarely been accounted for. In this paper, we propose sGraSP, a graph-based approach for the derivation of subject-specific functional parcellations. Our method generates first a common parcellation for an entire population, which is then adapted to each subject individually. Several cortical parcellations were generated for 859 children being part of the Philadelphia Neurodevelopmental Cohort. The stability of the parcellations generated by sGraSP was tested by mixing population and subject rs-fMRI signals, to generate subject-specific parcels increasingly closer to the population parcellation. We also checked if the parcels generated by our method were better capturing a development trend underlying our data than the original parcels, defined for the entire population. We compared sGraSP with a simpler and faster approach based on a Voronoi tessellation, by measuring their ability to produce functionally coherent parcels adapted to the subject data. Our parcellations outperformed the Voronoi tessellations. The parcels generated by sGraSP vary consistently with respect to signal mixing, the results are highly reproducible and the neurodevelopmental trend is better captured with the subject-specific parcellation, under all the signal mixing conditions.
AbstractList Resting-state fMRI (rs-fMRI) has emerged as a prominent tool for the study of functional connectivity. The identification of the regions associated with the different brain functions has received significant interest. However, most of the studies conducted so far have focused on the definition of a common set of regions, valid for an entire population. The variation of the functional regions within a population has rarely been accounted for.BACKGROUNDResting-state fMRI (rs-fMRI) has emerged as a prominent tool for the study of functional connectivity. The identification of the regions associated with the different brain functions has received significant interest. However, most of the studies conducted so far have focused on the definition of a common set of regions, valid for an entire population. The variation of the functional regions within a population has rarely been accounted for.In this paper, we propose sGraSP, a graph-based approach for the derivation of subject-specific functional parcellations. Our method generates first a common parcellation for an entire population, which is then adapted to each subject individually.NEW METHODIn this paper, we propose sGraSP, a graph-based approach for the derivation of subject-specific functional parcellations. Our method generates first a common parcellation for an entire population, which is then adapted to each subject individually.Several cortical parcellations were generated for 859 children being part of the Philadelphia Neurodevelopmental Cohort. The stability of the parcellations generated by sGraSP was tested by mixing population and subject rs-fMRI signals, to generate subject-specific parcels increasingly closer to the population parcellation. We also checked if the parcels generated by our method were better capturing a development trend underlying our data than the original parcels, defined for the entire population.RESULTSSeveral cortical parcellations were generated for 859 children being part of the Philadelphia Neurodevelopmental Cohort. The stability of the parcellations generated by sGraSP was tested by mixing population and subject rs-fMRI signals, to generate subject-specific parcels increasingly closer to the population parcellation. We also checked if the parcels generated by our method were better capturing a development trend underlying our data than the original parcels, defined for the entire population.We compared sGraSP with a simpler and faster approach based on a Voronoi tessellation, by measuring their ability to produce functionally coherent parcels adapted to the subject data.COMPARISON WITH EXISTING METHODSWe compared sGraSP with a simpler and faster approach based on a Voronoi tessellation, by measuring their ability to produce functionally coherent parcels adapted to the subject data.Our parcellations outperformed the Voronoi tessellations. The parcels generated by sGraSP vary consistently with respect to signal mixing, the results are highly reproducible and the neurodevelopmental trend is better captured with the subject-specific parcellation, under all the signal mixing conditions.CONCLUSIONSOur parcellations outperformed the Voronoi tessellations. The parcels generated by sGraSP vary consistently with respect to signal mixing, the results are highly reproducible and the neurodevelopmental trend is better captured with the subject-specific parcellation, under all the signal mixing conditions.
•We describe sGraSP, a novel subject-specific functional parcellation method.•sGraSP is tested using a large neurodevelopmental cohort (859 scans total).•Additional tests are generated by mixing subject and population signal.•sGraSP outperforms simpler approaches based on Voronoi tessellations.•Neurodevelopmental trends are robustly captured by sGraSP for all the signal mixing. Resting-state fMRI (rs-fMRI) has emerged as a prominent tool for the study of functional connectivity. The identification of the regions associated with the different brain functions has received significant interest. However, most of the studies conducted so far have focused on the definition of a common set of regions, valid for an entire population. The variation of the functional regions within a population has rarely been accounted for. In this paper, we propose sGraSP, a graph-based approach for the derivation of subject-specific functional parcellations. Our method generates first a common parcellation for an entire population, which is then adapted to each subject individually. Several cortical parcellations were generated for 859 children being part of the Philadelphia Neurodevelopmental Cohort. The stability of the parcellations generated by sGraSP was tested by mixing population and subject rs-fMRI signals, to generate subject-specific parcels increasingly closer to the population parcellation. We also checked if the parcels generated by our method were better capturing a development trend underlying our data than the original parcels, defined for the entire population. We compared sGraSP with a simpler and faster approach based on a Voronoi tessellation, by measuring their ability to produce functionally coherent parcels adapted to the subject data. Our parcellations outperformed the Voronoi tessellations. The parcels generated by sGraSP vary consistently with respect to signal mixing, the results are highly reproducible and the neurodevelopmental trend is better captured with the subject-specific parcellation, under all the signal mixing conditions.
Resting-state fMRI (rs-fMRI) has emerged as a prominent tool for the study of functional connectivity. The identification of the regions associated with the different brain functions has received significant interest. However, most of the studies conducted so far have focused on the definition of a common set of regions, valid for an entire population. The variation of the functional regions within a population has rarely been accounted for. In this paper, we propose sGraSP, a graph-based approach for the derivation of subject-specific functional parcellations. Our method generates first a common parcellation for an entire population, which is then adapted to each subject individually. Several cortical parcellations were generated for 859 children being part of the Philadelphia Neurodevelopmental Cohort. The stability of the parcellations generated by sGraSP was tested by mixing population and subject rs-fMRI signals, to generate subject-specific parcels increasingly closer to the population parcellation. We also checked if the parcels generated by our method were better capturing a development trend underlying our data than the original parcels, defined for the entire population. We compared sGraSP with a simpler and faster approach based on a Voronoi tessellation, by measuring their ability to produce functionally coherent parcels adapted to the subject data. Our parcellations outperformed the Voronoi tessellations. The parcels generated by sGraSP vary consistently with respect to signal mixing, the results are highly reproducible and the neurodevelopmental trend is better captured with the subject-specific parcellation, under all the signal mixing conditions.
Author Satterthwaite, T.D.
Gur, R.E.
Davatzikos, C.
Honnorat, N.
Gur, R.C.
AuthorAffiliation a Center for Biomedical Image Computing and Analytics, Department of Radiology, University of Pennsylvania, Philadelphia PA 19104, USA
b Brain and Behavior Laboratory, Department of Psychiatry, University of Pennsylvania, Philadelphia PA 19104, USA
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Snippet •We describe sGraSP, a novel subject-specific functional parcellation method.•sGraSP is tested using a large neurodevelopmental cohort (859 scans...
Resting-state fMRI (rs-fMRI) has emerged as a prominent tool for the study of functional connectivity. The identification of the regions associated with the...
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StartPage 1
SubjectTerms Adolescent
Algorithms
Brain - diagnostic imaging
Child
Cohort Studies
Computer Graphics
Connectome
Female
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Models, Neurological
Oxygen - blood
Parcellation
Rest
Rs-fMRI
Tessellation
Young Adult
Title sGraSP: A graph-based method for the derivation of subject-specific functional parcellations of the brain
URI https://dx.doi.org/10.1016/j.jneumeth.2016.11.014
https://www.ncbi.nlm.nih.gov/pubmed/27913211
https://www.proquest.com/docview/1845837765
https://pubmed.ncbi.nlm.nih.gov/PMC5253302
Volume 277
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