sGraSP: A graph-based method for the derivation of subject-specific functional parcellations of the brain
•We describe sGraSP, a novel subject-specific functional parcellation method.•sGraSP is tested using a large neurodevelopmental cohort (859 scans total).•Additional tests are generated by mixing subject and population signal.•sGraSP outperforms simpler approaches based on Voronoi tessellations.•Neur...
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Published in | Journal of neuroscience methods Vol. 277; pp. 1 - 20 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
Elsevier B.V
01.02.2017
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Abstract | •We describe sGraSP, a novel subject-specific functional parcellation method.•sGraSP is tested using a large neurodevelopmental cohort (859 scans total).•Additional tests are generated by mixing subject and population signal.•sGraSP outperforms simpler approaches based on Voronoi tessellations.•Neurodevelopmental trends are robustly captured by sGraSP for all the signal mixing.
Resting-state fMRI (rs-fMRI) has emerged as a prominent tool for the study of functional connectivity. The identification of the regions associated with the different brain functions has received significant interest. However, most of the studies conducted so far have focused on the definition of a common set of regions, valid for an entire population. The variation of the functional regions within a population has rarely been accounted for.
In this paper, we propose sGraSP, a graph-based approach for the derivation of subject-specific functional parcellations. Our method generates first a common parcellation for an entire population, which is then adapted to each subject individually.
Several cortical parcellations were generated for 859 children being part of the Philadelphia Neurodevelopmental Cohort. The stability of the parcellations generated by sGraSP was tested by mixing population and subject rs-fMRI signals, to generate subject-specific parcels increasingly closer to the population parcellation. We also checked if the parcels generated by our method were better capturing a development trend underlying our data than the original parcels, defined for the entire population.
We compared sGraSP with a simpler and faster approach based on a Voronoi tessellation, by measuring their ability to produce functionally coherent parcels adapted to the subject data.
Our parcellations outperformed the Voronoi tessellations. The parcels generated by sGraSP vary consistently with respect to signal mixing, the results are highly reproducible and the neurodevelopmental trend is better captured with the subject-specific parcellation, under all the signal mixing conditions. |
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AbstractList | Resting-state fMRI (rs-fMRI) has emerged as a prominent tool for the study of functional connectivity. The identification of the regions associated with the different brain functions has received significant interest. However, most of the studies conducted so far have focused on the definition of a common set of regions, valid for an entire population. The variation of the functional regions within a population has rarely been accounted for.BACKGROUNDResting-state fMRI (rs-fMRI) has emerged as a prominent tool for the study of functional connectivity. The identification of the regions associated with the different brain functions has received significant interest. However, most of the studies conducted so far have focused on the definition of a common set of regions, valid for an entire population. The variation of the functional regions within a population has rarely been accounted for.In this paper, we propose sGraSP, a graph-based approach for the derivation of subject-specific functional parcellations. Our method generates first a common parcellation for an entire population, which is then adapted to each subject individually.NEW METHODIn this paper, we propose sGraSP, a graph-based approach for the derivation of subject-specific functional parcellations. Our method generates first a common parcellation for an entire population, which is then adapted to each subject individually.Several cortical parcellations were generated for 859 children being part of the Philadelphia Neurodevelopmental Cohort. The stability of the parcellations generated by sGraSP was tested by mixing population and subject rs-fMRI signals, to generate subject-specific parcels increasingly closer to the population parcellation. We also checked if the parcels generated by our method were better capturing a development trend underlying our data than the original parcels, defined for the entire population.RESULTSSeveral cortical parcellations were generated for 859 children being part of the Philadelphia Neurodevelopmental Cohort. The stability of the parcellations generated by sGraSP was tested by mixing population and subject rs-fMRI signals, to generate subject-specific parcels increasingly closer to the population parcellation. We also checked if the parcels generated by our method were better capturing a development trend underlying our data than the original parcels, defined for the entire population.We compared sGraSP with a simpler and faster approach based on a Voronoi tessellation, by measuring their ability to produce functionally coherent parcels adapted to the subject data.COMPARISON WITH EXISTING METHODSWe compared sGraSP with a simpler and faster approach based on a Voronoi tessellation, by measuring their ability to produce functionally coherent parcels adapted to the subject data.Our parcellations outperformed the Voronoi tessellations. The parcels generated by sGraSP vary consistently with respect to signal mixing, the results are highly reproducible and the neurodevelopmental trend is better captured with the subject-specific parcellation, under all the signal mixing conditions.CONCLUSIONSOur parcellations outperformed the Voronoi tessellations. The parcels generated by sGraSP vary consistently with respect to signal mixing, the results are highly reproducible and the neurodevelopmental trend is better captured with the subject-specific parcellation, under all the signal mixing conditions. •We describe sGraSP, a novel subject-specific functional parcellation method.•sGraSP is tested using a large neurodevelopmental cohort (859 scans total).•Additional tests are generated by mixing subject and population signal.•sGraSP outperforms simpler approaches based on Voronoi tessellations.•Neurodevelopmental trends are robustly captured by sGraSP for all the signal mixing. Resting-state fMRI (rs-fMRI) has emerged as a prominent tool for the study of functional connectivity. The identification of the regions associated with the different brain functions has received significant interest. However, most of the studies conducted so far have focused on the definition of a common set of regions, valid for an entire population. The variation of the functional regions within a population has rarely been accounted for. In this paper, we propose sGraSP, a graph-based approach for the derivation of subject-specific functional parcellations. Our method generates first a common parcellation for an entire population, which is then adapted to each subject individually. Several cortical parcellations were generated for 859 children being part of the Philadelphia Neurodevelopmental Cohort. The stability of the parcellations generated by sGraSP was tested by mixing population and subject rs-fMRI signals, to generate subject-specific parcels increasingly closer to the population parcellation. We also checked if the parcels generated by our method were better capturing a development trend underlying our data than the original parcels, defined for the entire population. We compared sGraSP with a simpler and faster approach based on a Voronoi tessellation, by measuring their ability to produce functionally coherent parcels adapted to the subject data. Our parcellations outperformed the Voronoi tessellations. The parcels generated by sGraSP vary consistently with respect to signal mixing, the results are highly reproducible and the neurodevelopmental trend is better captured with the subject-specific parcellation, under all the signal mixing conditions. Resting-state fMRI (rs-fMRI) has emerged as a prominent tool for the study of functional connectivity. The identification of the regions associated with the different brain functions has received significant interest. However, most of the studies conducted so far have focused on the definition of a common set of regions, valid for an entire population. The variation of the functional regions within a population has rarely been accounted for. In this paper, we propose sGraSP, a graph-based approach for the derivation of subject-specific functional parcellations. Our method generates first a common parcellation for an entire population, which is then adapted to each subject individually. Several cortical parcellations were generated for 859 children being part of the Philadelphia Neurodevelopmental Cohort. The stability of the parcellations generated by sGraSP was tested by mixing population and subject rs-fMRI signals, to generate subject-specific parcels increasingly closer to the population parcellation. We also checked if the parcels generated by our method were better capturing a development trend underlying our data than the original parcels, defined for the entire population. We compared sGraSP with a simpler and faster approach based on a Voronoi tessellation, by measuring their ability to produce functionally coherent parcels adapted to the subject data. Our parcellations outperformed the Voronoi tessellations. The parcels generated by sGraSP vary consistently with respect to signal mixing, the results are highly reproducible and the neurodevelopmental trend is better captured with the subject-specific parcellation, under all the signal mixing conditions. |
Author | Satterthwaite, T.D. Gur, R.E. Davatzikos, C. Honnorat, N. Gur, R.C. |
AuthorAffiliation | a Center for Biomedical Image Computing and Analytics, Department of Radiology, University of Pennsylvania, Philadelphia PA 19104, USA b Brain and Behavior Laboratory, Department of Psychiatry, University of Pennsylvania, Philadelphia PA 19104, USA |
AuthorAffiliation_xml | – name: a Center for Biomedical Image Computing and Analytics, Department of Radiology, University of Pennsylvania, Philadelphia PA 19104, USA – name: b Brain and Behavior Laboratory, Department of Psychiatry, University of Pennsylvania, Philadelphia PA 19104, USA |
Author_xml | – sequence: 1 givenname: N. surname: Honnorat fullname: Honnorat, N. email: nicolas.honnorat@uphs.upenn.edu organization: Center for Biomedical Image Computing and Analytics, Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA – sequence: 2 givenname: T.D. surname: Satterthwaite fullname: Satterthwaite, T.D. organization: Center for Biomedical Image Computing and Analytics, Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA – sequence: 3 givenname: R.E. surname: Gur fullname: Gur, R.E. organization: Brain and Behavior Laboratory, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA – sequence: 4 givenname: R.C. surname: Gur fullname: Gur, R.C. organization: Brain and Behavior Laboratory, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA – sequence: 5 givenname: C. surname: Davatzikos fullname: Davatzikos, C. email: christos.davatzikos@uphs.upenn.edu organization: Center for Biomedical Image Computing and Analytics, Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27913211$$D View this record in MEDLINE/PubMed |
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CitedBy_id | crossref_primary_10_1016_j_media_2024_103297 crossref_primary_10_1186_s40708_018_0083_0 crossref_primary_10_1016_j_ijpsycho_2019_01_002 crossref_primary_10_1016_j_conb_2018_12_010 crossref_primary_10_1038_s41598_020_73328_1 |
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Snippet | •We describe sGraSP, a novel subject-specific functional parcellation method.•sGraSP is tested using a large neurodevelopmental cohort (859 scans... Resting-state fMRI (rs-fMRI) has emerged as a prominent tool for the study of functional connectivity. The identification of the regions associated with the... |
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SubjectTerms | Adolescent Algorithms Brain - diagnostic imaging Child Cohort Studies Computer Graphics Connectome Female Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging Male Models, Neurological Oxygen - blood Parcellation Rest Rs-fMRI Tessellation Young Adult |
Title | sGraSP: A graph-based method for the derivation of subject-specific functional parcellations of the brain |
URI | https://dx.doi.org/10.1016/j.jneumeth.2016.11.014 https://www.ncbi.nlm.nih.gov/pubmed/27913211 https://www.proquest.com/docview/1845837765 https://pubmed.ncbi.nlm.nih.gov/PMC5253302 |
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