Diabetic kidney disease: a role for advanced glycation end-product receptor 1 (AGE-R1)?

• Published in: Glycoconjugate journal Vol. 33; no. 4; pp. 645 - 652
• Main Authors: Zhuang, Aowen, Forbes, Josephine M.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.08.2016; Springer Nature B.V
• Subjects: Animals; Biochemistry; Biomedical and Life Sciences; Diabetes; Diabetic Nephropathies - metabolism; Diabetic Nephropathies - pathology; Diabetic neuropathy; Glycation End Products, Advanced - metabolism; Humans; Kidney diseases; Life Sciences; Mini-Review; Pathology; Receptor for Advanced Glycation End Products - metabolism; Diabetic nephropathy; AGEs; Diabetes; OST-48; AGE-R1; Diabetic kidney disease

Diabetic patients are postulated to be in a perpetual state of oxidative stress and inflammation at sites where chronic complications occur. The accumulation of AGEs derived from both endogenous and exogenous sources (such as the diet) have been implicated in the development and progression of diabe...