HSP90: a promising broad-spectrum antiviral drug target

• Published in: Archives of virology Vol. 162; no. 11; pp. 3269 - 3282
• Main Authors: Wang, Yiliang, Jin, Fujun, Wang, Rongze, Li, Feng, Wu, Yanting, Kitazato, Kaio, Wang, Yifei
• Format: Journal Article
• Language: English
• Published: Vienna Springer Vienna 01.11.2017; Springer Nature B.V
• Subjects: Animals; Antiviral agents; Antiviral Agents - pharmacology; Antiviral drugs; Biomedical and Life Sciences; Biomedicine; Clinical trials; Drug development; Drug resistance; Heat shock proteins; HSP90 Heat-Shock Proteins - metabolism; Hsp90 protein; Humans; Immune response; Immunosuppressive agents; Infectious Diseases; Life cycles; mechanism of action; Medical Microbiology; mutants; neoplasms; Nuclear transport; Parasites; physiological transport; Replication; Resistant mutant; Review; therapeutics; Transcription; Viral infections; Virology; Virus Diseases - drug therapy; Virus Diseases - metabolism; Virus Diseases - virology; Virus Replication - drug effects; virus transmission; viruses

The emergence of antiviral drug-resistant mutants is the most important issue in current antiviral therapy. As obligate parasites, viruses require host factors for efficient replication. An ideal therapeutic target to prevent drug-resistance development is represented by host factors that are crucia...