Proteasome dysfunction triggers activation of SKN-1A/Nrf1 by the aspartic protease DDI-1

• Published in: eLife Vol. 5
• Main Authors: Lehrbach, Nicolas J, Ruvkun, Gary
• Format: Journal Article
• Language: English
• Published: England eLife Sciences Publications Ltd 16.08.2016; eLife Sciences Publications, Ltd
• Subjects: Animals; Aspartic Acid Proteases - metabolism; Aspartic endopeptidase; aspartic protease; Bacteria; Caenorhabditis elegans - enzymology; Caenorhabditis elegans - metabolism; Caenorhabditis elegans Proteins - metabolism; Cancer; Cell Biology; Developmental Biology and Stem Cells; DNA-Binding Proteins - metabolism; E coli; ER traffic; Gene Expression Regulation; Genes; Homeostasis; Mutation; N-glycanase; Nematodes; peptide N-glycanase; proteasome; Proteasome Endopeptidase Complex - metabolism; Proteasomes; Protein interaction; Proteins; Proteolysis; SKN-1A/Nrf1; Software; Transcription activation; Transcription factors; Transcription Factors - metabolism; proteasome; stem cells; C. elegans; cell biology; ER traffic; developmental biology; SKN-1A/Nrf1; peptide N-glycanase; aspartic protease

Proteasomes are essential for protein homeostasis in eukaryotes. To preserve cellular function, transcription of proteasome subunit genes is induced in response to proteasome dysfunction caused by pathogen attacks or proteasome inhibitor drugs. In Caenorhabditis elegans, this response requires SKN-1...