Advances in the Management of HPV-Related Oropharyngeal Cancer
Patients with human papillomavirus- (HPV-) related oropharyngeal squamous cell carcinoma (OPSCC) have a better prognosis than HPV-negative OPSCC when treated with standard high-dose cisplatin-based chemoradiotherapy. Consistent with this assertion and due to younger age at diagnosis, novel approache...
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| Published in | Journal of oncology Vol. 2019; no. 2019; pp. 1 - 8 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Cairo, Egypt
Hindawi Publishing Corporation
01.01.2019
Hindawi Hindawi Limited |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Patients with human papillomavirus- (HPV-) related oropharyngeal squamous cell carcinoma (OPSCC) have a better prognosis than HPV-negative OPSCC when treated with standard high-dose cisplatin-based chemoradiotherapy. Consistent with this assertion and due to younger age at diagnosis, novel approaches to minimize treatment sequelae while preserving survival outcomes become of paramount importance. Here, we critically reviewed the evidence-based literature supporting the deintensification strategies in HPV-related OPSCC management, including radiotherapy dose and/or volume reduction, replacement of cisplatin radiosensitising chemotherapy, and the use of transoral surgery. Undoubtedly, further researches are needed before changing the standard of care in this setting of patients. |
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| AbstractList | Patients with human papillomavirus- (HPV-) related oropharyngeal squamous cell carcinoma (OPSCC) have a better prognosis than HPV-negative OPSCC when treated with standard high-dose cisplatin-based chemoradiotherapy. Consistent with this assertion and due to younger age at diagnosis, novel approaches to minimize treatment sequelae while preserving survival outcomes become of paramount importance. Here, we critically reviewed the evidence-based literature supporting the deintensification strategies in HPV-related OPSCC management, including radiotherapy dose and/or volume reduction, replacement of cisplatin radiosensitising chemotherapy, and the use of transoral surgery. Undoubtedly, further researches are needed before changing the standard of care in this setting of patients. |
| Author | Polimeni, A. de Vincentiis, M. Brugnoletti, O. Mezi, S. De Felice, Francesca Valentini, V. Tombolini, V. |
| AuthorAffiliation | 3 Department of Medical Oncology, Policlinico Umberto I “Sapienza” University of Rome, Rome, Italy 1 Department of Radiotherapy, Policlinico Umberto I, “Sapienza” University of Rome, Rome, Italy 2 Department of Oral and Maxillofacial Sciences, Policlinico Umberto I, “Sapienza” University of Rome, Rome, Italy |
| AuthorAffiliation_xml | – name: 3 Department of Medical Oncology, Policlinico Umberto I “Sapienza” University of Rome, Rome, Italy – name: 1 Department of Radiotherapy, Policlinico Umberto I, “Sapienza” University of Rome, Rome, Italy – name: 2 Department of Oral and Maxillofacial Sciences, Policlinico Umberto I, “Sapienza” University of Rome, Rome, Italy |
| Author_xml | – sequence: 1 fullname: Polimeni, A. – sequence: 2 fullname: Mezi, S. – sequence: 3 fullname: de Vincentiis, M. – sequence: 4 fullname: Valentini, V. – sequence: 5 fullname: Tombolini, V. – sequence: 6 fullname: De Felice, Francesca – sequence: 7 fullname: Brugnoletti, O. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31097964$$D View this record in MEDLINE/PubMed |
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| ContentType | Journal Article |
| Copyright | Copyright © 2019 F. De Felice et al. Copyright © 2019 F. De Felice et al. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Copyright © 2019 F. De Felice et al. 2019 |
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| Title | Advances in the Management of HPV-Related Oropharyngeal Cancer |
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