The Bedtime Administration Ameliorates Blood Pressure Variability and Reduces Urinary Albumin Excretion in Amlodipine-Olmesartan Combination Therapy

• Published in: Clinical and experimental hypertension (1993) Vol. 32; no. 7; pp. 416 - 422
• Main Authors: Hoshino, Atsushi, Nakamura, Takeshi, Matsubara, Hiroaki
• Format: Journal Article
• Language: English
• Published: England Informa Healthcare 01.11.2010; Taylor & Francis
• Subjects: Adult; Aged; Aged, 80 and over; Albumins - analysis; Amlodipine - administration & dosage; Amlodipine - therapeutic use; Antihypertensive Agents - administration & dosage; Antihypertensive Agents - therapeutic use; Blood Pressure - drug effects; Blood Pressure Monitoring, Ambulatory; blood pressure viability; chronotherapy; combination therapy; Creatinine - urine; Drug Chronotherapy; Drug Therapy, Combination; Female; Humans; Hypertension - drug therapy; Hypertension - physiopathology; Hypertension - urine; Imidazoles - administration & dosage; Imidazoles - therapeutic use; Male; Middle Aged; morning blood pressure surge (MBPS); Tetrazoles - administration & dosage; Tetrazoles - therapeutic use; Treatment Outcome; urinary albumin excretion

Chronotherapy has the potential to improve blood pressure (BP) variability and to decrease stroke and cardiovascular events. The present study examined the efficacy and safety of the bedtime administration in amlodipine-olmesartan combination therapy, as compared with the morning administration. The...