GBA mutations increase risk for Lewy body disease with and without Alzheimer disease pathology

• Published in: Neurology Vol. 79; no. 19; p. 1944
• Main Authors: Tsuang, Debby, Leverenz, James B, Lopez, Oscar L, Hamilton, Ronald L, Bennett, David A, Schneider, Julie A, Buchman, Aron S, Larson, Eric B, Crane, Paul K, Kaye, Jeffrey A, Kramer, Patricia, Woltjer, Randy, Kukull, Walter, Nelson, Peter T, Jicha, Gregory A, Neltner, Janna H, Galasko, Doug, Masliah, Eliezer, Trojanowski, John Q, Schellenberg, Gerard D, Yearout, Dora, Huston, Haley, Fritts-Penniman, Allison, Mata, Ignacio F, Wan, Jia Y, Edwards, Karen L, Montine, Thomas J, Zabetian, Cyrus P
• Format: Journal Article
• Language: English
• Published: United States 06.11.2012
• Subjects: Aged; Aged, 80 and over; alpha-Synuclein - metabolism; Alzheimer Disease - complications; Alzheimer Disease - pathology; DNA Mutational Analysis; Female; Frontal Lobe - metabolism; Frontal Lobe - pathology; Glucosylceramidase - genetics; Humans; Lewy Body Disease - complications; Lewy Body Disease - genetics; Logistic Models; Male; Middle Aged; Mutation; Mutation Rate; Risk Factors

Mutations in the GBA gene occur in 7% of patients with Parkinson disease (PD) and are a well-established susceptibility factor for PD, which is characterized by Lewy body disease (LBD) neuropathologic changes (LBDNCs). We sought to determine whether GBA influences risk of dementia with LBDNCs, Alzhe...