Keratinocyte Growth Factor-2 Reduces Inflammatory Response to Acute Lung Injury Induced by Oleic Acid in Rats by Regulating Key Proteins of the Wnt/β-Catenin Signaling Pathway
Reducing inflammation can effectively relieve acute lung injury (ALI). Objective. To test whether keratinocyte growth factor-2 (KGF-2) can reduce oleic acid-induced inflammation in ALI of rats and explore its possible mechanism. Methods. 45 Sprague-Dawley rats were randomly divided into control grou...
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Published in | Evidence-based complementary and alternative medicine Vol. 2020; no. 2020; pp. 1 - 9 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
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Cairo, Egypt
Hindawi Publishing Corporation
2020
Hindawi Hindawi Limited |
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Abstract | Reducing inflammation can effectively relieve acute lung injury (ALI). Objective. To test whether keratinocyte growth factor-2 (KGF-2) can reduce oleic acid-induced inflammation in ALI of rats and explore its possible mechanism. Methods. 45 Sprague-Dawley rats were randomly divided into control group, ALI group, and ALI + KGF-2 group. The animal model of acute lung injury was established by injecting 0.1 mL/kg oleic acid into the tail vein of rats. Rats in the control group were injected with equal volume of normal saline (NS). Each group needs pretreatment 72 hours before the preparation of the acute lung injury model. The control group and ALI group were instilled with 5 ml/kg NS through the airway, and the same amount of KGF-2 was instilled in the ALI + KGF-2 group. It takes 8 hours to successfully prepare the ALI model. Observe the pathological changes of lung tissue through light microscopy, ultrastructural changes through electron microscopy, and the lung wettability/dry weight (w/d) ratio and lung permeability index (LPI). By detecting changes in inflammatory factors in lung tissue and changes in the number of BALF cells, the changes in inflammation in each group were observed. The expressions of Wnt5a, β-catenin, and APC in lung tissue were detected by immunohistochemistry and Western blot. The changes of key proteins in Wnt/β-catenin signaling pathway in the lung tissue of each group were observed. Result. Compared with the ALI group, after KGF-2 pretreatment, the degree of lung injury was reduced, the expression of inflammatory factors was reduced, and the number of red blood cells and white blood cells in BALF was reduced. It can also be observed that the expression of Wnt5a, β-catenin, and APC, a key protein in the Wnt/β-catenin signaling pathway, is reduced. The analysis showed that the number of inflammatory factors, red blood cells, and white blood cells in BALF was positively correlated with the expression of Wnt5a, β-catenin, and APC. Conclusion. KGF-2 may reduce the inflammatory response in ALI induced by oleic acid by regulating key proteins in the Wnt/β-catenin signaling pathway. |
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AbstractList | Reducing inflammation can effectively relieve acute lung injury (ALI). Objective . To test whether keratinocyte growth factor‐2 (KGF‐2) can reduce oleic acid‐induced inflammation in ALI of rats and explore its possible mechanism. Methods . 45 Sprague‐Dawley rats were randomly divided into control group, ALI group, and ALI + KGF‐2 group. The animal model of acute lung injury was established by injecting 0.1 mL/kg oleic acid into the tail vein of rats. Rats in the control group were injected with equal volume of normal saline (NS). Each group needs pretreatment 72 hours before the preparation of the acute lung injury model. The control group and ALI group were instilled with 5 ml/kg NS through the airway, and the same amount of KGF‐2 was instilled in the ALI + KGF‐2 group. It takes 8 hours to successfully prepare the ALI model. Observe the pathological changes of lung tissue through light microscopy, ultrastructural changes through electron microscopy, and the lung wettability/dry weight (w/d) ratio and lung permeability index (LPI). By detecting changes in inflammatory factors in lung tissue and changes in the number of BALF cells, the changes in inflammation in each group were observed. The expressions of Wnt5a, β ‐catenin, and APC in lung tissue were detected by immunohistochemistry and Western blot. The changes of key proteins in Wnt/ β ‐catenin signaling pathway in the lung tissue of each group were observed. Result . Compared with the ALI group, after KGF‐2 pretreatment, the degree of lung injury was reduced, the expression of inflammatory factors was reduced, and the number of red blood cells and white blood cells in BALF was reduced. It can also be observed that the expression of Wnt5a, β ‐catenin, and APC, a key protein in the Wnt/ β ‐catenin signaling pathway, is reduced. The analysis showed that the number of inflammatory factors, red blood cells, and white blood cells in BALF was positively correlated with the expression of Wnt5a, β ‐catenin, and APC. Conclusion . KGF‐2 may reduce the inflammatory response in ALI induced by oleic acid by regulating key proteins in the Wnt/ β ‐catenin signaling pathway. Reducing inflammation can effectively relieve acute lung injury (ALI). Objective . To test whether keratinocyte growth factor-2 (KGF-2) can reduce oleic acid-induced inflammation in ALI of rats and explore its possible mechanism. Methods . 45 Sprague-Dawley rats were randomly divided into control group, ALI group, and ALI + KGF-2 group. The animal model of acute lung injury was established by injecting 0.1 mL/kg oleic acid into the tail vein of rats. Rats in the control group were injected with equal volume of normal saline (NS). Each group needs pretreatment 72 hours before the preparation of the acute lung injury model. The control group and ALI group were instilled with 5 ml/kg NS through the airway, and the same amount of KGF-2 was instilled in the ALI + KGF-2 group. It takes 8 hours to successfully prepare the ALI model. Observe the pathological changes of lung tissue through light microscopy, ultrastructural changes through electron microscopy, and the lung wettability/dry weight (w/d) ratio and lung permeability index (LPI). By detecting changes in inflammatory factors in lung tissue and changes in the number of BALF cells, the changes in inflammation in each group were observed. The expressions of Wnt5a, β -catenin, and APC in lung tissue were detected by immunohistochemistry and Western blot. The changes of key proteins in Wnt/ β -catenin signaling pathway in the lung tissue of each group were observed. Result . Compared with the ALI group, after KGF-2 pretreatment, the degree of lung injury was reduced, the expression of inflammatory factors was reduced, and the number of red blood cells and white blood cells in BALF was reduced. It can also be observed that the expression of Wnt5a, β -catenin, and APC, a key protein in the Wnt/ β -catenin signaling pathway, is reduced. The analysis showed that the number of inflammatory factors, red blood cells, and white blood cells in BALF was positively correlated with the expression of Wnt5a, β -catenin, and APC. Conclusion . KGF-2 may reduce the inflammatory response in ALI induced by oleic acid by regulating key proteins in the Wnt/ β -catenin signaling pathway. Reducing inflammation can effectively relieve acute lung injury (ALI). . To test whether keratinocyte growth factor-2 (KGF-2) can reduce oleic acid-induced inflammation in ALI of rats and explore its possible mechanism. . 45 Sprague-Dawley rats were randomly divided into control group, ALI group, and ALI + KGF-2 group. The animal model of acute lung injury was established by injecting 0.1 mL/kg oleic acid into the tail vein of rats. Rats in the control group were injected with equal volume of normal saline (NS). Each group needs pretreatment 72 hours before the preparation of the acute lung injury model. The control group and ALI group were instilled with 5 ml/kg NS through the airway, and the same amount of KGF-2 was instilled in the ALI + KGF-2 group. It takes 8 hours to successfully prepare the ALI model. Observe the pathological changes of lung tissue through light microscopy, ultrastructural changes through electron microscopy, and the lung wettability/dry weight (w/d) ratio and lung permeability index (LPI). By detecting changes in inflammatory factors in lung tissue and changes in the number of BALF cells, the changes in inflammation in each group were observed. The expressions of Wnt5a, -catenin, and APC in lung tissue were detected by immunohistochemistry and Western blot. The changes of key proteins in Wnt/ -catenin signaling pathway in the lung tissue of each group were observed. . Compared with the ALI group, after KGF-2 pretreatment, the degree of lung injury was reduced, the expression of inflammatory factors was reduced, and the number of red blood cells and white blood cells in BALF was reduced. It can also be observed that the expression of Wnt5a, -catenin, and APC, a key protein in the Wnt/ -catenin signaling pathway, is reduced. The analysis showed that the number of inflammatory factors, red blood cells, and white blood cells in BALF was positively correlated with the expression of Wnt5a, -catenin, and APC. . KGF-2 may reduce the inflammatory response in ALI induced by oleic acid by regulating key proteins in the Wnt/ -catenin signaling pathway. |
Author | Zhanbiao, Yu Xigang, M. Kuo, Wang Shenghai, Wang Tenghao, S. Qinlong, Sun Ning, Chen Jiaqian, Wu |
AuthorAffiliation | 1 Department of Critical Care Medicine, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, China 2 Department of Critical Care Medicine, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004, China |
AuthorAffiliation_xml | – name: 1 Department of Critical Care Medicine, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, China – name: 2 Department of Critical Care Medicine, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004, China |
Author_xml | – sequence: 1 fullname: Xigang, M. – sequence: 2 fullname: Kuo, Wang – sequence: 3 fullname: Jiaqian, Wu – sequence: 4 fullname: Qinlong, Sun – sequence: 5 fullname: Shenghai, Wang – sequence: 6 fullname: Ning, Chen – sequence: 7 fullname: Tenghao, S. – sequence: 8 fullname: Zhanbiao, Yu |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32655669$$D View this record in MEDLINE/PubMed |
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CitedBy_id | crossref_primary_10_1016_j_intimp_2022_108690 crossref_primary_10_1002_wsbm_1549 crossref_primary_10_1007_s12011_022_03461_7 crossref_primary_10_1111_jocd_15957 crossref_primary_10_1155_2021_8889408 crossref_primary_10_1016_j_biopha_2023_115896 crossref_primary_10_1016_j_yexcr_2021_112762 crossref_primary_10_1155_2022_3055039 |
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Copyright | Copyright © 2020 Shao Tenghao et al. Copyright © 2020 Shao Tenghao et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://creativecommons.org/licenses/by/4.0 Copyright © 2020 Shao Tenghao et al. 2020 |
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Snippet | Reducing inflammation can effectively relieve acute lung injury (ALI). Objective. To test whether keratinocyte growth factor-2 (KGF-2) can reduce oleic... Reducing inflammation can effectively relieve acute lung injury (ALI). . To test whether keratinocyte growth factor-2 (KGF-2) can reduce oleic acid-induced... Reducing inflammation can effectively relieve acute lung injury (ALI). Objective . To test whether keratinocyte growth factor‐2 (KGF‐2) can reduce oleic... Reducing inflammation can effectively relieve acute lung injury (ALI). Objective . To test whether keratinocyte growth factor-2 (KGF-2) can reduce oleic... |
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SubjectTerms | Animal models Antibodies Blood Catheters Electron microscopy Erythrocytes Growth factors Immunohistochemistry Inflammation Keratinocyte growth factor Leukocytes Light microscopy Lungs Oleic acid Permeability Proteins Signal transduction Software Stains & staining Statistical analysis Variance analysis Veins & arteries Wnt protein β-Catenin |
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Title | Keratinocyte Growth Factor-2 Reduces Inflammatory Response to Acute Lung Injury Induced by Oleic Acid in Rats by Regulating Key Proteins of the Wnt/β-Catenin Signaling Pathway |
URI | https://search.emarefa.net/detail/BIM-1157510 https://dx.doi.org/10.1155/2020/8350579 https://www.ncbi.nlm.nih.gov/pubmed/32655669 https://www.proquest.com/docview/2417978681 https://search.proquest.com/docview/2423513333 https://pubmed.ncbi.nlm.nih.gov/PMC7322598 |
Volume | 2020 |
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