Oxidative Stress Protection by Exogenous Delivery of rhHsp70 Chaperone to the Retinal Pigment Epithelium (RPE), a Possible Therapeutic Strategy Against RPE Degeneration - Subrizi, Astrid; Toropainen, Elisa; Ramsay, Eva; Airaksinen, Anu J.; Kaarniranta, Kai; Urtti, Arto (Pharmaceutical research, 2015)
Keywords: Animals; Biochemistry; Biomedical and Life Sciences; Biomedical Engineering and Bioengineering; Biomedicine; Cell Culture Techniques; Cell Line; Cell Survival - drug effects; Cellular biology; Heat shock proteins; HSP70 Heat-Shock Proteins - administration & dosage; HSP70 Heat-Shock Proteins - pharmacokinetics; HSP70 Heat-Shock Proteins - therapeutic use; Humans; Hydrogen Peroxide - toxicity; Interleukin-6 - secretion; Intravitreal Injections; Macular Degeneration - immunology; Macular Degeneration - metabolism; Macular Degeneration - pathology; Macular Degeneration - prevention & control; Medical Law; Oxidative stress; Oxidative Stress - drug effects; Pharmaceutical sciences; Pharmacology/Toxicology; Pharmacy; Recombinant Proteins; Research Paper; Retina; Retinal Pigment Epithelium - drug effects; Retinal Pigment Epithelium - immunology; Retinal Pigment Epithelium - metabolism; Retinal Pigment Epithelium - pathology; Swine; Tissue Distribution; AMD; Protein delivery; Oxidative stress; Hsp70; RPE