The role of lipoxygenases in pathophysiology; new insights and future perspectives

• Published in: Redox biology Vol. 6; pp. 297 - 310
• Main Authors: Mashima, Ryuichi, Okuyama, Torayuki
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier 01.12.2015
• Subjects: 5-Lipoxygenase-Activating Proteins - genetics; 5-Lipoxygenase-Activating Proteins - metabolism; Animals; Anti-Asthmatic Agents - therapeutic use; Arachidonate 12-Lipoxygenase - genetics; Arachidonate 12-Lipoxygenase - metabolism; Arachidonate 15-Lipoxygenase - genetics; Arachidonate 15-Lipoxygenase - metabolism; Asthma - drug therapy; Asthma - enzymology; Asthma - genetics; Asthma - pathology; Clinical Trials as Topic; Gene Expression; Humans; Ichthyosis - drug therapy; Ichthyosis - enzymology; Ichthyosis - genetics; Ichthyosis - pathology; Indoles - therapeutic use; Lipoxygenase - genetics; Lipoxygenase - metabolism; Mice; Neoplasms - drug therapy; Neoplasms - enzymology; Neoplasms - genetics; Neoplasms - pathology; Pentanoic Acids - therapeutic use; Review; Signal transduction; Phenotype; Resolvins; Lipoxygenase

Lipoxygenases (LOXs) are dioxygenases that catalyze the formation of corresponding hydroperoxides from polyunsaturated fatty acids such as linoleic acid and arachidonic acid. LOX enzymes are expressed in immune, epithelial, and tumor cells that display a variety of physiological functions, including...