Comparative effects of dexmedetomidine, propofol, sevoflurane, and S-ketamine on regional cerebral glucose metabolism in humans: a positron emission tomography study

• Published in: British journal of anaesthesia : BJA Vol. 121; no. 1; pp. 281 - 290
• Main Authors: Laaksonen, L., Kallioinen, M., Långsjö, J., Laitio, T., Scheinin, A., Scheinin, J., Kaisti, K., Maksimow, A., Kallionpää, R.E., Rajala, V., Johansson, J., Kantonen, O., Nyman, M., Sirén, S., Valli, K., Revonsuo, A., Solin, O., Vahlberg, T., Alkire, M., Scheinin, H.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.07.2018
• Subjects: cerebral blood flow; cerebral metabolism; Consciousness and Cognitive Neuroscience; Kognitiv neurovetenskap och filosofi; positron emission tomography; sedation; target-controlled infusion; cerebral blood flow; target-controlled infusion; positron emission tomography; sedation; cerebral metabolism

The highly selective α2-agonist dexmedetomidine has become a popular sedative for neurointensive care patients. However, earlier studies have raised concern that dexmedetomidine might reduce cerebral blood flow without a concomitant decrease in metabolism. Here, we compared the effects of dexmedetom...