New Autopsy Findings in Different Brain Regions of a Preterm Neonate With Kernicterus: Neurovascular Alterations and Up-regulation of Efflux Transporters

• Published in: Pediatric neurology Vol. 49; no. 6; pp. 431 - 438
• Main Authors: Brito, Maria A., PhD, Pereira, Pedro, MSc, Barroso, Cândida, MD, Aronica, Eleonora, MD, PhD, Brites, Dora, PhD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2013
• Subjects: albumin; Albumins - metabolism; Antigens, CD34 - metabolism; Autopsy; Blood Vessels - pathology; blood-brain barrier; Brain - metabolism; Brain - pathology; Claudin-5 - metabolism; corpus striatum; efflux transporters; Female; Glial Fibrillary Acidic Protein - metabolism; hippocampus; Humans; Infant; kernicterus; Kernicterus - diagnosis; Male; microvascularization; Multidrug Resistance-Associated Proteins - metabolism; Neurology; Pediatrics; Premature Birth; vascular endothelial growth factor; Vascular Endothelial Growth Factor A - metabolism; Vascular Endothelial Growth Factor Receptor-2 - metabolism; blood-brain barrier; corpus striatum; hippocampus; kernicterus; vascular endothelial growth factor; albumin; microvascularization; efflux transporters

Abstract Background Kernicterus is an irreversible brain damage caused by bilirubin deposition in selective brain regions. Sick and preterm infants with hyperbilirubinemia are particularly susceptible to the condition. Methods We studied autopsied brain tissue from a premature female infant with ker...