Spatial regulation of a common precursor from two distinct genes generates metabolite diversity

• Published in: Chemical science (Cambridge) Vol. 6; no. 10; pp. 5913 - 5921
• Main Authors: Guo, Chun-Jun, Sun, Wei-Wen, Bruno, Kenneth S., Oakley, Berl R., Keller, Nancy P., Wang, Clay C. C.
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 01.10.2015
• Subjects: BASIC BIOLOGICAL SCIENCES; Biosynthesis; Chemistry; Enzymes; Gene expression; Genes; Metabolites; Pathways; Precursors; Proteins

In secondary metabolite biosynthesis, core synthetic genes such as polyketide synthase genes usually encode proteins that generate various backbone precursors. These precursors are modified by other tailoring enzymes to yield a large variety of different secondary metabolites. The number of core syn...