Comprehensive Association Analyses of Extraintestinal Manifestations in Inflammatory Bowel Disease

• Published in: Gastroenterology (New York, N.Y. 1943) Vol. 167; no. 2; pp. 315 - 332
• Main Authors: Khrom, Michelle, Long, Millie, Dube, Shishir, Robbins, Lori, Botwin, Gregory J., Yang, Shaohong, Mengesha, Emebet, Li, Dalin, Naito, Takeo, Bonthala, Nirupama N., Ha, Christina, Melmed, Gil, Rabizadeh, Shervin, Syal, Gaurav, Vasiliauskas, Eric, Ziring, David, Brant, Steven R., Cho, Judy, Duerr, Richard H., Rioux, John, Schumm, Phil, Silverberg, Mark, Ananthakrishnan, Ashwin N., Faubion, William A., Jabri, Bana, Lira, Sergio A., Newberry, Rodney D., Sandler, Robert S., Xavier, Ramnik J., Kugathasan, Subra, Hercules, David, Targan, Stephan R., Sartor, R. Balfour, Haritunians, Talin, McGovern, Dermot P.B.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2024
• Subjects: Adolescent; Adult; Aged; Child; Cholangitis, Sclerosing - complications; Cholangitis, Sclerosing - diagnosis; Cholangitis, Sclerosing - genetics; Cholangitis, Sclerosing - immunology; Colitis, Ulcerative - diagnosis; Colitis, Ulcerative - genetics; Colitis, Ulcerative - immunology; Crohn Disease - diagnosis; Crohn Disease - genetics; Crohn Disease - immunology; Extraintestinal Manifestations; Eye Diseases - diagnosis; Eye Diseases - epidemiology; Eye Diseases - etiology; Eye Diseases - genetics; Eye Diseases - immunology; Female; Genetic Predisposition to Disease; Genetics; Humans; Inflammatory Bowel Disease; Inflammatory Bowel Diseases - diagnosis; Inflammatory Bowel Diseases - genetics; Inflammatory Bowel Diseases - immunology; Logistic Models; Male; Middle Aged; Phenotype; Risk Factors; Serology; Sex Factors; Skin Diseases - etiology; Skin Diseases - genetics; Skin Diseases - immunology; Spondylitis, Ankylosing - complications; Spondylitis, Ankylosing - diagnosis; Spondylitis, Ankylosing - genetics; Spondylitis, Ankylosing - immunology; Young Adult; SKIN-3; MHC; Serology; IBD; SHARE; TNF; ASCA; UC; anti-I2; EYE; anti-OmpC; QC; Extraintestinal Manifestations; SNP; ANCA; Genetics; CSMC; Inflammatory Bowel Disease; NIDDK; CD; PSC; OR; Ps; EIM; EN; RISK; AS-SI; 2 EIMs; QSS; PA; anti-CBir1; AS; PG; LD; EIM-6; EIM-7
• ISSN: 0016-5085; 1528-0012; 1528-0012
• DOI: 10.1053/j.gastro.2024.02.026

Patients with inflammatory bowel disease (IBD) frequently develop extraintestinal manifestations (EIMs) that contribute substantially to morbidity. We assembled the largest multicohort data set to date to investigate the clinical, serologic, and genetic factors associated with EIM complications in I...