Function of heterochromatin protein 1 during DNA repair

• Published in: Protoplasma Vol. 254; no. 3; pp. 1233 - 1240
• Main Authors: Bártová, Eva, Malyšková, Barbora, Komůrková, Denisa, Legartová, Soňa, Suchánková, Jana, Krejčí, Jana, Kozubek, Stanislav
• Format: Journal Article Book Review
• Language: English
• Published: Vienna Springer Vienna 01.05.2017; Springer Nature B.V
• Subjects: Biomedical and Life Sciences; Cell Biology; Chromatin - metabolism; Chromosomal Proteins, Non-Histone - metabolism; DNA Damage - genetics; DNA Repair - genetics; Humans; Life Sciences; Plant Sciences; Proliferating Cell Nuclear Antigen - metabolism; Protein Processing, Post-Translational; Repressor Proteins - metabolism; Review Article; Tripartite Motif-Containing Protein 28; Zoology; HP1 protein; DNA damage response; DNA repair

This review focuses on the function of heterochromatin protein HP1 in response to DNA damage. We specifically outline the regulatory mechanisms in which HP1 and its interacting partners are involved. HP1 protein subtypes (HP1α, HP1β, and HP1γ) are the main components of constitutive heterochromatin,...